Literature DB >> 17713083

Halogen-magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids.

Felix Kopp1, Stefan Wunderlich, Paul Knochel.   

Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl.LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

Entities:  

Year:  2007        PMID： 17713083     DOI： 10.1039/b618923g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

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Authors:  Ian S Young; Phil S Baran
Journal:  Nat Chem       Date:  2009-06       Impact factor: 24.427

2.  Synthesis of the diaryl ether cores common to chrysophaentins A, E and F.

Authors:  Anthony J Brockway; Charles I Grove; Maximillian E Mahoney; Jared T Shaw
Journal:  Tetrahedron Lett       Date:  2015-06-03       Impact factor: 2.415

3.  Nonclassical SNAPFL analogue as a Cy5 resonance energy transfer partner.

Authors:  Sung Hoon Kim; Jillian R Gunther; John A Katzenellenbogen
Journal:  Org Lett       Date:  2008-10-09       Impact factor: 6.005

4.  Main group multiple C-H/N-H bond activation of a diamine and isolation of a molecular dilithium zincate hydride: experimental and DFT evidence for alkali metal-zinc synergistic effects.

Authors:  Ross Campbell; Daniel Cannon; Pablo García-Álvarez; Alan R Kennedy; Robert E Mulvey; Stuart D Robertson; Jörg Sassmannshausen; Tell Tuttle
Journal:  J Am Chem Soc       Date:  2011-08-04       Impact factor: 15.419
  4 in total

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