Literature DB >> 17712533

Mechanisms of tumor growth and metastasis in head and neck squamous cell carcinoma.

Jarrett E Walsh1, Deanne M R Lathers, Angela C Chi, M Boyd Gillespie, Terry A Day, M Rita I Young.   

Abstract

The formation and progression of head and neck squamous cell carcinoma (HNSCC) is multisystemic and involves the immune system, vascularization, and dissemination. Immune involvement includes the subversion of anti-tumor defenses. Vascularization involves both angiogenesis and vasculogenesis. Dissemination involves local tumor invasion as well as distant metastasis through processes including angiogenesis and lymphangiogenesis. Current studies in the dysregulation of various processes, including genetic stability, angiogenesis, lymphangiogenesis, immune regulation, and immune function, are opening opportunities for the development of targeted tumor therapies. The interrelationship of these processes in HNSCC development will be explored in this review.

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Year:  2007        PMID: 17712533     DOI: 10.1007/s11864-007-0032-2

Source DB:  PubMed          Journal:  Curr Treat Options Oncol        ISSN: 1534-6277


  75 in total

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  16 in total

Review 1.  Molecular mechanisms of head and neck cancer.

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Journal:  Expert Rev Anticancer Ther       Date:  2008-05       Impact factor: 4.512

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Journal:  Oral Oncol       Date:  2014-10-14       Impact factor: 5.337

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Journal:  Int Rev Immunol       Date:  2012-02       Impact factor: 5.311

7.  Vasculogenesis driven by bone marrow-derived cells is essential for growth of Ewing's sarcomas.

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Authors:  Jennifer K Mulligan; Terry A Day; M Boyd Gillespie; Steven A Rosenzweig; M Rita I Young
Journal:  Hum Immunol       Date:  2009-02-12       Impact factor: 2.850

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