| Literature DB >> 17712315 |
M Fendt1, S Schmid, D R Thakker, L H Jacobson, R Yamamoto, K Mitsukawa, R Maier, F Natt, D Hüsken, P H Kelly, K H McAllister, D Hoyer, H van der Putten, J F Cryan, P J Flor.
Abstract
Formation and extinction of aversive memories in the mammalian brain are insufficiently understood at the cellular and molecular levels. Using the novel metabotropic glutamate receptor 7 (mGluR7) agonist AMN082, we demonstrate that mGluR7 activation facilitates the extinction of aversive memories in two different amygdala-dependent tasks. Conversely, mGluR7 knockdown using short interfering RNA attenuated the extinction of learned aversion. mGluR7 activation also blocked the acquisition of Pavlovian fear learning and its electrophysiological correlate long-term potentiation in the amygdala. The finding that mGluR7 critically regulates extinction, in addition to acquisition of aversive memories, demonstrates that this receptor may be relevant for the manifestation and treatment of anxiety disorders.Entities:
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Year: 2007 PMID： 17712315 DOI： 10.1038/sj.mp.4002073
Source DB: PubMed Journal: Mol Psychiatry ISSN： 1359-4184 Impact factor: 15.992