Dysmyelinating leukodystrophies: "LACK Proper Myelin".

A mnemonic has been developed, "LACK Proper Myelin", which can serve as a spring board in developing a differential diagnosis in a child with a dysmyelinating leukodystrophy. Certain distinguishing features of the diseases can be used including laboratory evaluation, head size and sex of the child. The important common ground that all the dysmyelinating leukodystrophies share, they all are inherited disorders that have a enzymatic or biochemical abnormality resulting in the development of abnormal myelin.