BACKGROUND: The aim of this study was to find out whether the beneficial effects of the renin-angiotensin-aldosterone system (RAS) blockage in chronic kidney disease (CKD) has any relation with the alteration of asymmetric dimethylarginine (ADMA) levels. METHODS: Sixty-six nondiabetic patients with CKD and proteinuria and 36 healthy subjects were enrolled. Patients were treated with either ramipril 5 mg daily or valsartan 160 mg daily for 3 months. Proteinuria, ADMA, symmetric dimethyl arginine (SDMA), flow-mediated dilatation (FMD) and HOMA index measurements were performed both before and after the treatment. RESULTS: ADMA, SDMA, hsCRP levels, HOMA index and proteinuria of patients were significantly higher (p < 0.001 for all) and FMD, L-arginine and L-arginine/ADMA ratio in CKD were significantly lower than controls. According to the multiple regression analysis, proteinuria levels were independently related to ADMA and SDMA levels. CONCLUSION: Both drugs were equally effective in reducing elevated ADMA levels and improving endothelial dysfunction in CKD patients. Copyright 2007 S. Karger AG, Basel.
BACKGROUND: The aim of this study was to find out whether the beneficial effects of the renin-angiotensin-aldosterone system (RAS) blockage in chronic kidney disease (CKD) has any relation with the alteration of asymmetric dimethylarginine (ADMA) levels. METHODS: Sixty-six nondiabeticpatients with CKD and proteinuria and 36 healthy subjects were enrolled. Patients were treated with either ramipril 5 mg daily or valsartan 160 mg daily for 3 months. Proteinuria, ADMA, symmetric dimethyl arginine (SDMA), flow-mediated dilatation (FMD) and HOMA index measurements were performed both before and after the treatment. RESULTS:ADMA, SDMA, hsCRP levels, HOMA index and proteinuria of patients were significantly higher (p < 0.001 for all) and FMD, L-arginine and L-arginine/ADMA ratio in CKD were significantly lower than controls. According to the multiple regression analysis, proteinuria levels were independently related to ADMA and SDMA levels. CONCLUSION: Both drugs were equally effective in reducing elevated ADMA levels and improving endothelial dysfunction in CKDpatients. Copyright 2007 S. Karger AG, Basel.
Authors: Ruth F Dubin; Alexis L Beatty; John R Teerlink; Nelson B Schiller; Ann F Bolger; Dean Alokozai; Carmen A Peralta; Kirsten L Johansen Journal: Hemodial Int Date: 2013-11-14 Impact factor: 1.812
Authors: Munna Lal Patel; Rekha Sachan; Gaurav Prakash Singh; S C Chaudhary; K K Gupta; Virendra Atam; Anit Parihar Journal: J Family Med Prim Care Date: 2019-04