Literature DB >> 17709468

Growth and drug resistance phenotypes resulting from cytomegalovirus DNA polymerase region III mutations observed in clinical specimens.

Sunwen Chou1, Gail I Marousek, Laura C Van Wechel, Shaobing Li, Adriana Weinberg.   

Abstract

Recombinant phenotyping of cytomegalovirus (CMV) pol region III mutations from clinical specimens showed that T813S and G841A each conferred foscarnet resistance and approximately threefold increased ganciclovir resistance; adding the UL97 mutation C592G increased ganciclovir resistance to approximately sixfold. Bacterial artificial chromosome CMV clones containing pol mutation L845P were nonviable unless repaired with the wild-type sequence.

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Year:  2007        PMID： 17709468      PMCID： PMC2151462          DOI： 10.1128/AAC.00736-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  14 in total

Review 1.  Human cytomegalovirus resistance to antiviral drugs.

Authors:  C Gilbert; G Boivin
Journal:  Antimicrob Agents Chemother       Date:  2005-03       Impact factor: 5.191

2.  Phenotyping of cytomegalovirus drug resistance mutations by using recombinant viruses incorporating a reporter gene.

Authors:  Sunwen Chou; Laura C Van Wechel; Heather M Lichy; Gail I Marousek
Journal:  Antimicrob Agents Chemother       Date:  2005-07       Impact factor: 5.191

3.  Mutation in region III of the DNA polymerase gene conferring foscarnet resistance in cytomegalovirus isolates from 3 subjects receiving prolonged antiviral therapy.

Authors:  S Chou; G Marousek; D M Parenti; S M Gordon; A G LaVoy; J G Ross; R C Miner; W L Drew
Journal:  J Infect Dis       Date:  1998-08       Impact factor: 5.226

4.  Evolution of mutations conferring multidrug resistance during prophylaxis and therapy for cytomegalovirus disease.

Authors:  S Chou; G Marousek; S Guentzel; S E Follansbee; M E Poscher; J P Lalezari; R C Miner; W L Drew
Journal:  J Infect Dis       Date:  1997-09       Impact factor: 5.226

5.  Cloning of the human cytomegalovirus (HCMV) genome as an infectious bacterial artificial chromosome in Escherichia coli: a new approach for construction of HCMV mutants.

Authors:  E M Borst; G Hahn; U H Koszinowski; M Messerle
Journal:  J Virol       Date:  1999-10       Impact factor: 5.103

6.  Antiviral susceptibilities and analysis of UL97 and DNA polymerase sequences of clinical cytomegalovirus isolates from immunocompromised patients.

Authors:  A Erice; C Gil-Roda; J L Pérez; H H Balfour; K J Sannerud; M N Hanson; G Boivin; S Chou
Journal:  J Infect Dis       Date:  1997-05       Impact factor: 5.226

7.  A point mutation in the human cytomegalovirus DNA polymerase gene selected in vitro by cidofovir confers a slow replication phenotype in cell culture.

Authors:  T Cihlar; M D Fuller; A S Mulato; J M Cherrington
Journal:  Virology       Date:  1998-09-01       Impact factor: 3.616

8.  Characterization of drug resistance-associated mutations in the human cytomegalovirus DNA polymerase gene by using recombinant mutant viruses generated from overlapping DNA fragments.

Authors:  T Cihlar; M D Fuller; J M Cherrington
Journal:  J Virol       Date:  1998-07       Impact factor: 5.103

9.  A protein kinase homologue controls phosphorylation of ganciclovir in human cytomegalovirus-infected cells.

Authors:  V Sullivan; C L Talarico; S C Stanat; M Davis; D M Coen; K K Biron
Journal:  Nature       Date:  1992-07-09       Impact factor: 49.962

10.  Simple and highly efficient BAC recombineering using galK selection.

Authors:  Søren Warming; Nina Costantino; Donald L Court; Nancy A Jenkins; Neal G Copeland
Journal:  Nucleic Acids Res       Date:  2005-02-24       Impact factor: 16.971
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  25 in total

Review 1.  Management of cytomegalovirus infection in solid organ transplantation.

Authors:  Camille N Kotton
Journal:  Nat Rev Nephrol       Date:  2010-10-26       Impact factor: 28.314

2.  Differentiation between polymorphisms and resistance-associated mutations in human cytomegalovirus DNA polymerase.

Authors:  Meike Chevillotte; Ina Ersing; Thomas Mertens; Jens von Einem
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

3.  Phenotypic evaluation of previously uncharacterized cytomegalovirus DNA polymerase sequence variants detected in a valganciclovir treatment trial.

Authors:  Sunwen Chou; Guy Boivin; Jane Ives; Robert Elston
Journal:  J Infect Dis       Date:  2013-11-23       Impact factor: 5.226

4.  Contrasting drug resistance phenotypes resulting from cytomegalovirus DNA polymerase mutations at the same exonuclease locus.

Authors:  Sunwen Chou; Gail Marousek; Shaobing Li; Adriana Weinberg
Journal:  J Clin Virol       Date:  2008-05-27       Impact factor: 3.168

5.  Selection and recombinant phenotyping of a novel CMX001 and cidofovir resistance mutation in human cytomegalovirus.

Authors:  Scott H James; Nathan B Price; Caroll B Hartline; E Randall Lanier; Mark N Prichard
Journal:  Antimicrob Agents Chemother       Date:  2013-05-06       Impact factor: 5.191

6.  Cytomegalovirus UL97 kinase catalytic domain mutations that confer multidrug resistance.

Authors:  Sunwen Chou; Ronald J Ercolani; Gail Marousek; Terry L Bowlin
Journal:  Antimicrob Agents Chemother       Date:  2013-05-06       Impact factor: 5.191

7.  Recombinant phenotyping of cytomegalovirus UL54 mutations that emerged during cell passages in the presence of either ganciclovir or foscarnet.

Authors:  Christian Gilbert; Arezki Azzi; Nathalie Goyette; Sheng-Xiang Lin; Guy Boivin
Journal:  Antimicrob Agents Chemother       Date:  2011-06-27       Impact factor: 5.191

8.  Differentiated Levels of Ganciclovir Resistance Conferred by Mutations at Codons 591 to 603 of the Cytomegalovirus UL97 Kinase Gene.

Authors:  Sunwen Chou; Ronald J Ercolani; Adam L Vanarsdall
Journal:  J Clin Microbiol       Date:  2017-04-26       Impact factor: 5.948

9.  Characterization of multiple cytomegalovirus drug resistance mutations detected in a hematopoietic stem cell transplant recipient by recombinant phenotyping.

Authors:  Emilien Drouot; Jocelyne Piret; Marc H Lebel; Guy Boivin
Journal:  J Clin Microbiol       Date:  2014-08-20       Impact factor: 5.948

10.  Rapid In Vitro Evolution of Human Cytomegalovirus UL56 Mutations That Confer Letermovir Resistance.

Authors:  Sunwen Chou
Journal:  Antimicrob Agents Chemother       Date:  2015-08-10       Impact factor: 5.191
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