| Literature DB >> 17709241 |
Sharmistha Sinha1, Garima Gupta, Mamannamana Vijayan, Avadhesha Surolia.
Abstract
Lectins are a structurally diverse group of carbohydrate recognizing proteins that are involved in various biological processes and exhibit substantial structural diversity. Interestingly, in spite of having varied carbohydrate-binding specificities, they show modest variation in their secondary and tertiary structure. However, very similar tertiary folds give rise to a range of quaternary structures by simply varying the mutual orientations of the subunits involved. The variety in the quaternary structure generates multivalency in sugar specificities among lectins along with the requisite surface topology to allow for unobstructed recognition events.Entities:
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Year: 2007 PMID: 17709241 DOI: 10.1016/j.sbi.2007.06.007
Source DB: PubMed Journal: Curr Opin Struct Biol ISSN: 0959-440X Impact factor: 6.809