Literature DB >> 17708980

The search for physiological substrates of MAP and SAP kinases in mammalian cells.

P Cohen.   

Abstract

Mitogen-activated protein kinases (MAPKs) and stress-activated protein kinases (SAPKs) respond to many extracellular signals, but the large number of these enzymes and their overlapping specificities in vitro has made it extremely difficult to identify the physiological roles and substrates of individual family members. This review discusses recent progress in understanding some of the functions of these enzymes that has been made possible by the introduction of some novel approaches, particularly the use of two specific inhibitors.

Entities:  

Year:  1997        PMID： 17708980     DOI： 10.1016/S0962-8924(97)01105-7

Source DB:  PubMed          Journal:  Trends Cell Biol        ISSN： 0962-8924            Impact factor:   20.808


  114 in total

1.  Signalling-competent truncated forms of ErbB2 in breast cancer cells: differential regulation by protein kinase C and phosphatidylinositol 3-kinase.

Authors:  A Esparís-Ogando; E Díaz-Rodríguez; A Pandiella
Journal:  Biochem J       Date:  1999-12-01       Impact factor: 3.857

2.  The Usf-1 transcription factor is a novel target for the stress-responsive p38 kinase and mediates UV-induced Tyrosinase expression.

Authors:  M D Galibert; S Carreira; C R Goding
Journal:  EMBO J       Date:  2001-09-03       Impact factor: 11.598

3.  Mitogen-activated protein kinase-dependent and -independent routes control shedding of transmembrane growth factors through multiple secretases.

Authors:  Juan Carlos Montero; Laura Yuste; Elena Díaz-Rodríguez; Azucena Esparís-Ogando; Atanasio Pandiella
Journal:  Biochem J       Date:  2002-04-15       Impact factor: 3.857

4.  Role of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression.

Authors:  Jiping Chen; Mark F Stinski
Journal:  J Virol       Date:  2002-05       Impact factor: 5.103

5.  Brain tissue responses to ischemia.

Authors:  J M Lee; M C Grabb; G J Zipfel; D W Choi
Journal:  J Clin Invest       Date:  2000-09       Impact factor: 14.808

6.  Acute modulation of the extent of apoB mRNA editing and the relative rates of syntheses of apoB48 and apoB100 in cultured rat hepatocytes by osmotic and other stress stimuli.

Authors:  A McCahill; D J Lankester; B S Park; N T Price; V A Zammit
Journal:  Mol Cell Biochem       Date:  2000-05       Impact factor: 3.396

7.  Activation of transcription of the human cytomegalovirus early UL4 promoter by the Ets transcription factor binding element.

Authors:  J Chen; M F Stinski
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

8.  Nitric oxide regulation of calcitonin gene-related peptide gene expression in rat trigeminal ganglia neurons.

Authors:  Jamie Bellamy; Elizabeth J Bowen; Andrew F Russo; Paul L Durham
Journal:  Eur J Neurosci       Date:  2006-04       Impact factor: 3.386

9.  Up-regulation of c-jun mRNA in cardiac myocytes requires the extracellular signal-regulated kinase cascade, but c-Jun N-terminal kinases are required for efficient up-regulation of c-Jun protein.

Authors:  Angela Clerk; Timothy J Kemp; Joanne G Harrison; Anthony J Mullen; Paul J R Barton; Peter H Sugden
Journal:  Biochem J       Date:  2002-11-15       Impact factor: 3.857

10.  Identification of glycogen synthase as a new substrate for stress-activated protein kinase 2b/p38beta.

Authors:  Yvonne Kuma; David G Campbell; Ana Cuenda
Journal:  Biochem J       Date:  2004-04-01       Impact factor: 3.857
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