AIM: To evaluate ursodeoxycholic acid (UDCA) therapy on the in vitro contraction of gallbladder smooth muscle strips from cholesterol gallstone patients. METHODS: The contraction forces of gallbladder smooth muscle strips from 28 patients with cholesterol gallstones treated withUDCA were compared with contraction forces from 14 untreated patients. The strips were stimulated with increasing concentrations of cholecystokinin-8 (CCK-8). RESULTS: Although the contraction forces that developed in response to CCK-8 were higher in strips from specimens of UDCA treated patients compared to untreated patients, longer treatment periods (6-wk) caused more contraction responses than the short treatment period of 3-wk (F = 19.297, 1.85 +/- 0.22 g vs 1.70 +/- 0.10 g, P < 0.01). Contraction forces developed with maximal stimulation with KCl in the 6-wk treatment group were also higher than contraction forces in the untreated group (F = 4.274, 3.77 +/- 0.45 g vs 3.30 +/- 0.30 g, P < 0.05). CONCLUSION: Six-week UDCA treatment caused an increase in contractions of muscle strips from patients with cholesterol gallstones when compared to shorter treatment administration or controls. We suggest that extending UDCA treatment periods may cause more effective contractions in the gallbladder, and thereby increase the rate of response to treatment.
RCT Entities:
AIM: To evaluate ursodeoxycholic acid (UDCA) therapy on the in vitro contraction of gallbladder smooth muscle strips from cholesterol gallstonepatients. METHODS: The contraction forces of gallbladder smooth muscle strips from 28 patients with cholesterol gallstones treated with UDCA were compared with contraction forces from 14 untreated patients. The strips were stimulated with increasing concentrations of cholecystokinin-8 (CCK-8). RESULTS: Although the contraction forces that developed in response to CCK-8 were higher in strips from specimens of UDCA treated patients compared to untreated patients, longer treatment periods (6-wk) caused more contraction responses than the short treatment period of 3-wk (F = 19.297, 1.85 +/- 0.22 g vs 1.70 +/- 0.10 g, P < 0.01). Contraction forces developed with maximal stimulation with KCl in the 6-wk treatment group were also higher than contraction forces in the untreated group (F = 4.274, 3.77 +/- 0.45 g vs 3.30 +/- 0.30 g, P < 0.05). CONCLUSION: Six-week UDCA treatment caused an increase in contractions of muscle strips from patients with cholesterol gallstones when compared to shorter treatment administration or controls. We suggest that extending UDCA treatment periods may cause more effective contractions in the gallbladder, and thereby increase the rate of response to treatment.
Authors: K J van Erpecum; G P van Berge Henegouwen; M F Stolk; W P Hopman; J B Jansen; C B Lamers Journal: Gastroenterology Date: 1990-09 Impact factor: 22.682
Authors: D Festi; R Frabboni; F Bazzoli; A Sangermano; M Ronchi; L Rossi; P Parini; M Orsini; A M Primerano; G Mazzella Journal: Gastroenterology Date: 1990-12 Impact factor: 22.682
Authors: B J van de Heijning; P C van de Meeberg; P Portincasa; H Doornewaard; F J Hoebers; K J van Erpecum; G P Vanberge-Henegouwen Journal: Dig Dis Sci Date: 1999-01 Impact factor: 3.199