BACKGROUND AND OBJECTIVES: Pelvic exenteration offers the last chance of cure for some advanced or recurrent gynecologic malignancy patients. The aim of this prospective study was to analyze factors associated with recurrence and survival after pelvic exenteration. METHODS: Forty-six women with advanced or recurrent gynecologic malignancies were enrolled between July 2001 and February 2006. All pelvic exenteration surgery was performed by the same gynecological oncologist. RESULTS: Two patients were excluded due to the discovery of peritoneal disease during surgery. Multivariate analysis showed that a tumor size >4 cm was the only factor associated with risk of recurrence after surgery (P = 0.014), that margin status was the only factor associated with disease-free survival (P = 0.0.047), and that margin status and lymph node metastasis were associated with overall survival (P = 0.017 and 0.012, respectively). CONCLUSIONS: Pelvic exenteration and reconstruction was found to have a potential to provide long-term survival without postoperative mortality although the morbidity rate is somewhat high. Multivariate analysis showed that tumor size >4 cm was a predictive factor for recurrence, and that margin status and lymph node metastasis were predictive factors for survival.
BACKGROUND AND OBJECTIVES: Pelvic exenteration offers the last chance of cure for some advanced or recurrent gynecologic malignancypatients. The aim of this prospective study was to analyze factors associated with recurrence and survival after pelvic exenteration. METHODS: Forty-six women with advanced or recurrent gynecologic malignancies were enrolled between July 2001 and February 2006. All pelvic exenteration surgery was performed by the same gynecological oncologist. RESULTS: Two patients were excluded due to the discovery of peritoneal disease during surgery. Multivariate analysis showed that a tumor size >4 cm was the only factor associated with risk of recurrence after surgery (P = 0.014), that margin status was the only factor associated with disease-free survival (P = 0.0.047), and that margin status and lymph node metastasis were associated with overall survival (P = 0.017 and 0.012, respectively). CONCLUSIONS: Pelvic exenteration and reconstruction was found to have a potential to provide long-term survival without postoperative mortality although the morbidity rate is somewhat high. Multivariate analysis showed that tumor size >4 cm was a predictive factor for recurrence, and that margin status and lymph node metastasis were predictive factors for survival.
Authors: Olivio F Donati; Yulia Lakhman; Evis Sala; Irene A Burger; Hebert A Vargas; Debra A Goldman; Vaagn Andikyan; Kay J Park; Dennis S Chi; Hedvig Hricak Journal: Eur Radiol Date: 2013-05-08 Impact factor: 5.315
Authors: David A Iglesias; Shannon N Westin; Vijayashri Rallapalli; Marilyn Huang; Bryan Fellman; Diana Urbauer; Michael Frumovitz; Pedro T Ramirez; Pamela T Soliman Journal: Gynecol Oncol Date: 2012-01-16 Impact factor: 5.482
Authors: Sabine Hannes; Johanna M Nijboer; Alexander Reinisch; Wolf O Bechstein; Nils Habbe Journal: Indian J Surg Date: 2015-04-24 Impact factor: 0.656
Authors: Andrea Petruzziello; William Kondo; Sergio B Hatschback; João A Guerreiro; Flávio Panegalli Filho; Cristiano Vendrame; Murilo Luz; Reitan Ribeiro Journal: World J Surg Oncol Date: 2014-09-08 Impact factor: 2.754