| Literature DB >> 17707767 |
Li-Tian Yin1, Yue-Jun Fu, Qiao-Ling Xu, Jun Yang, Zeng-Li Liu, Ai-Hua Liang, Xiao-Jun Fan, Cheng-Gang Xu.
Abstract
Glioma is a highly invasive, rapidly spreading form of brain cancer that is resistant to surgical and medical treatment. The recent progresses made in intracellular and ion channels of glioma cells provide a potential new approach for biochemical therapy of brain tumor. In this paper, we reviewed clinical data on chemotherapy by temozolomide and results from new studies on voltage-gated potassium channels, large-conductance Ca(2+)-activated K(+) channels, volume-activated chloride channels, glioma-specific chloride channel and their modulators. These new findings may represent future directions for brain tumor studies and treatment.Entities:
Mesh:
Substances:
Year: 2007 PMID: 17707767 DOI: 10.1016/j.bbrc.2007.07.167
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN: 0006-291X Impact factor: 3.575