Literature DB >> 17707553

Insight into the reactive form of the anticancer agent iproplatin.

Erika Volckova1, Evelyne Weaver, Rathindra N Bose.   

Abstract

The reaction of iproplatin with reduced glutathione at different mole ratios yielded cis-di(isopropylamine)chloro-glutathionatoplatinum(II), not the expected cis-dichloro- species, indicating a mode of action of this anticancer agent that is different from that of cis-diamminedichloroplatinum(II).

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Year:  2007        PMID： 17707553     DOI： 10.1016/j.ejmech.2007.06.019

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  3 in total

Review 1.  Synthetic methods for the preparation of platinum anticancer complexes.

Authors:  Justin J Wilson; Stephen J Lippard
Journal:  Chem Rev       Date:  2013-11-27       Impact factor: 60.622

Review 2.  Anticancer activity of metal complexes: involvement of redox processes.

Authors:  Ute Jungwirth; Christian R Kowol; Bernhard K Keppler; Christian G Hartinger; Walter Berger; Petra Heffeter
Journal:  Antioxid Redox Signal       Date:  2011-05-11       Impact factor: 8.401

3.  Comparison of the effects of the oral anticancer platinum(IV) complexes oxoplatin and metabolite cis-diammine-tetrachlorido-platinum(IV) on global gene expression of NCI-H526 cells.

Authors:  Ulrike Olszewski; Ernst Ulsperger; Klaus Geissler; Gerhard Hamilton
Journal:  J Exp Pharmacol       Date:  2011-04-01
  3 in total

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