Literature DB >> 17707375

PKD is recruited to sites of actin remodelling at the leading edge and negatively regulates cell migration.

Tim Eiseler1, Michael A Schmid, Fitnat Topbas, Klaus Pfizenmaier, Angelika Hausser.   

Abstract

Protein kinase D (PKD) has been implicated in the regulation of cell shape, adhesion, and migration. At the leading edge of migrating cells active PKD co-localizes with F-actin, Arp3 and cortactin. Platelet derived growth factor (PDGF) activates PKD and recruits the kinase to the leading edge, suggesting a role for PKD in actin remodelling. In support of this, PKD directly interacts with F-actin and phosphorylates cortactin in vitro. Interference with PKD function by overexpression of a dominant negative PKD or by PKD-specific siRNA enhanced cell migration, whereas cells overexpressing PKD wild type displayed reduced migratory potential. Taken together, these data reveal a negative regulatory function of PKD in cell migration.

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Year:  2007        PMID： 17707375     DOI： 10.1016/j.febslet.2007.07.079

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  32 in total

1.  Regulation of VASP by phosphorylation: consequences for cell migration.

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Journal:  Cell Adh Migr       Date:  2013-12-05       Impact factor: 3.405

2.  Protein kinase D controls actin polymerization and cell motility through phosphorylation of cortactin.

Authors:  Tim Eiseler; Angelika Hausser; Line De Kimpe; Johan Van Lint; Klaus Pfizenmaier
Journal:  J Biol Chem       Date:  2010-04-02       Impact factor: 5.157

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Journal:  Mol Cancer Res       Date:  2011-06-16       Impact factor: 5.852

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5.  Loss of cell-cell contacts induces NF-kappaB via RhoA-mediated activation of protein kinase D1.

Authors:  Catherine F Cowell; Irene K Yan; Tim Eiseler; Amanda C Leightner; Heike Döppler; Peter Storz
Journal:  J Cell Biochem       Date:  2009-03-01       Impact factor: 4.429

6.  Kidins220/ARMS modulates the activity of microtubule-regulating proteins and controls neuronal polarity and development.

Authors:  Alonso M Higuero; Lucía Sánchez-Ruiloba; Laura E Doglio; Francisco Portillo; José Abad-Rodríguez; Carlos G Dotti; Teresa Iglesias
Journal:  J Biol Chem       Date:  2009-11-10       Impact factor: 5.157

7.  Protein kinase D controls the integrity of Golgi apparatus and the maintenance of dendritic arborization in hippocampal neurons.

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Journal:  Mol Biol Cell       Date:  2009-02-11       Impact factor: 4.138

8.  A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.

Authors:  Sahra Borges; Heike R Döppler; Peter Storz
Journal:  Breast Cancer Res Treat       Date:  2014-02-08       Impact factor: 4.872

9.  Protein kinase D1 regulates matrix metalloproteinase expression and inhibits breast cancer cell invasion.

Authors:  Tim Eiseler; Heike Döppler; Irene K Yan; Steve Goodison; Peter Storz
Journal:  Breast Cancer Res       Date:  2009-02-25       Impact factor: 6.466

10.  Protein kinase D1 regulates cofilin-mediated F-actin reorganization and cell motility through slingshot.

Authors:  Tim Eiseler; Heike Döppler; Irene K Yan; Kanae Kitatani; Kensaku Mizuno; Peter Storz
Journal:  Nat Cell Biol       Date:  2009-03-29       Impact factor: 28.824
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