Literature DB >> 17706646

Leishmania chagasi: homogenous metacyclic promastigotes isolated by buoyant density are highly virulent in a mouse model.

Chaoqun Yao1, Yani Chen, Bayan Sudan, John E Donelson, Mary E Wilson.   

Abstract

Homogenous metacyclic promastigotes of Leishmania chagasi were isolated by buoyant density from in vitro heterogeneous cultures and used for biochemical characterization of isoforms of the major surface protease (MSP). Compared to stationary phase promastigotes, metacyclic cells had three times more MSP, produced 3-fold higher parasite loads in a mouse model in vivo, and were more resistant to complement-mediated lysis in vitro. These metacyclic L. chagasi expressed both the virulence-associated 59-kDa, and the constitutively expressed 63-kDa, isoforms of MSP.

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Year:  2007        PMID： 17706646      PMCID： PMC2274777          DOI： 10.1016/j.exppara.2007.06.012

Source DB:  PubMed          Journal:  Exp Parasitol        ISSN： 0014-4894            Impact factor:   2.011


  28 in total

1.  Inducible resistance to oxidant stress in the protozoan Leishmania chagasi.

Authors:  M A Miller; S E McGowan; K R Gantt; M Champion; S L Novick; K A Andersen; C J Bacchi; N Yarlett; B E Britigan; M E Wilson
Journal:  J Biol Chem       Date:  2000-10-27       Impact factor: 5.157

2.  Interplay between parasite cysteine proteases and the host kinin system modulates microvascular leakage and macrophage infection by promastigotes of the Leishmania donovani complex.

Authors:  Erik Svensjö; Paulo R Batista; Claudia I Brodskyn; Robson Silva; Ana Paula C A Lima; Verônica Schmitz; Elvira Saraiva; João B Pesquero; Marcelo A S Mori; Werner Müller-Esterl; Julio Scharfstein
Journal:  Microbes Infect       Date:  2005-09-08       Impact factor: 2.700

3.  Regulation of GP63 mRNA stability in promastigotes of virulent and attenuated Leishmania chagasi.

Authors:  A Brittingham; M A Miller; J E Donelson; M E Wilson
Journal:  Mol Biochem Parasitol       Date:  2001-01-15       Impact factor: 1.759

4.  Presentation of the Leishmania antigen LACK by infected macrophages is dependent upon the virulence of the phagocytosed parasites.

Authors:  N Courret; E Prina; E Mougneau; E M Saraiva; D L Sacks; N Glaichenhaus; J C Antoine
Journal:  Eur J Immunol       Date:  1999-03       Impact factor: 5.532

5.  A lipophosphoglycan-independent method for isolation of infective Leishmania metacyclic promastigotes by density gradient centrifugation.

Authors:  G F Späth; S M Beverley
Journal:  Exp Parasitol       Date:  2001-10       Impact factor: 2.011

6.  Biosynthesis of the major surface protease GP63 of Leishmania chagasi.

Authors:  Chaoqun Yao; Kevin G Leidal; Andrew Brittingham; Deirdre E Tarr; John E Donelson; Mary E Wilson
Journal:  Mol Biochem Parasitol       Date:  2002-04-30       Impact factor: 1.759

7.  Internal and surface subpopulations of the major surface protease (MSP) of Leishmania chagasi.

Authors:  Chaoqun Yao; Jiwen Luo; Christine Hsiao; John E Donelson; Mary E Wilson
Journal:  Mol Biochem Parasitol       Date:  2005-02       Impact factor: 1.759

8.  Flow cytometric assessment of Leishmania spp metacyclic differentiation: validation by morphological features and specific markers.

Authors:  Elvira M Saraiva; Lucia H Pinto-da-Silva; João Luiz M Wanderley; Adriana C Bonomo; Marcello A Barcinski; Maria Elisabete C Moreira
Journal:  Exp Parasitol       Date:  2005-05       Impact factor: 2.011

9.  The role of mannose receptor during experimental leishmaniasis.

Authors:  Oleg E Akilov; Rachel E Kasuboski; Cristina R Carter; Mary Ann McDowell
Journal:  J Leukoc Biol       Date:  2007-01-29       Impact factor: 4.962

10.  Leishmania tropica: the identification and purification of metacyclic promastigotes and use in establishing mouse and hamster models of cutaneous and visceral disease.

Authors:  R Lira; S Méndez; L Carrera; C Jaffe; F Neva; D Sacks
Journal:  Exp Parasitol       Date:  1998-07       Impact factor: 2.011
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  30 in total

Review 1.  Receptor-mediated phagocytosis of Leishmania: implications for intracellular survival.

Authors:  Norikiyo Ueno; Mary E Wilson
Journal:  Trends Parasitol       Date:  2012-06-21

2.  Role of prostaglandin F2α production in lipid bodies from Leishmania infantum chagasi: insights on virulence.

Authors:  Théo Araújo-Santos; Nilda E Rodríguez; Sara Moura-Pontes; Upasna Gaur Dixt; Daniel R Abánades; Patrícia T Bozza; Mary E Wilson; Valéria Matos Borges
Journal:  J Infect Dis       Date:  2014-05-21       Impact factor: 5.226

3.  The effects of macrophage source on the mechanism of phagocytosis and intracellular survival of Leishmania.

Authors:  Chia-Hung Christine Hsiao; Norikiyo Ueno; Jian Q Shao; Kristin R Schroeder; Kenneth C Moore; John E Donelson; Mary E Wilson
Journal:  Microbes Infect       Date:  2011-06-30       Impact factor: 2.700

4.  Leishmania infantum chagasi: a genome-based approach to identification of excreted/secreted proteins.

Authors:  Sruti DebRoy; Alexandra B Keenan; Norikiyo Ueno; Selma M B Jeronimo; John E Donelson; Mary E Wilson
Journal:  Exp Parasitol       Date:  2010-06-11       Impact factor: 2.011

5.  Sand fly-Leishmania interactions: long relationships are not necessarily easy.

Authors:  Marcelo Ramalho-Ortigao; Elvira M Saraiva; Yara M Traub-Csekö
Journal:  Open Parasitol J       Date:  2010-01-01

6.  Proteomic examination of Leishmania chagasi plasma membrane proteins: Contrast between avirulent and virulent (metacyclic) parasite forms.

Authors:  Chaoqun Yao; Yalan Li; John E Donelson; Mary E Wilson
Journal:  Proteomics Clin Appl       Date:  2009-11-11       Impact factor: 3.494

7.  Reduced hamster usage and stress in propagating Leishmania chagasi promastigotes using cryopreservation and saphenous vein inoculation.

Authors:  Soi Meng Lei; Amanda E Ramer-Tait; Rebecca R Dahlin-Laborde; Kathleen Mullin; Jeffrey K Beetham
Journal:  J Parasitol       Date:  2010-02       Impact factor: 1.276

8.  Kinetic analysis of ex vivo human blood infection by Leishmania.

Authors:  Inmaculada Moreno; Mercedes Domínguez; Darío Cabañes; Carmen Aizpurua; Alfredo Toraño
Journal:  PLoS Negl Trop Dis       Date:  2010-07-13

9.  Differences in human macrophage receptor usage, lysosomal fusion kinetics and survival between logarithmic and metacyclic Leishmania infantum chagasi promastigotes.

Authors:  Norikiyo Ueno; Carol L Bratt; Nilda E Rodriguez; Mary E Wilson
Journal:  Cell Microbiol       Date:  2009-08-20       Impact factor: 3.715

10.  3'-nucleotidase/nuclease activity allows Leishmania parasites to escape killing by neutrophil extracellular traps.

Authors:  Anderson B Guimarães-Costa; Thiago S DeSouza-Vieira; Rafael Paletta-Silva; Anita Leocádio Freitas-Mesquita; José Roberto Meyer-Fernandes; Elvira M Saraiva
Journal:  Infect Immun       Date:  2014-02-10       Impact factor: 3.441
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