| Literature DB >> 17706424 |
Kyoji Furuta1, Masahide Maeda, Yoko Hirata, Shoko Shibata, Kazutoshi Kiuchi, Masaaki Suzuki.
Abstract
The synthesis and evaluation for anti- and proapoptotic properties of cyclopentenone prostaglandin analogs are described. Novel J-type analogs of NEPP11 with a cross-conjugated cyclopentadienone moiety and a lipophilic omega-side chain suppressed manganese ion-induced apoptosis of PC12 cells at comparable levels to NEPP11, while monoenone derivatives were inactive. The proapoptotic activities of J-type analogs were much lower than that of NEPP11. Natural 15-deoxy-Delta(12,14)-PGJ(2) and Delta(7)-PGA(1) methyl ester were highly toxic, inducing apoptosis at lower concentrations.Entities:
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Year: 2006 PMID： 17706424 DOI： 10.1016/j.bmcl.2006.12.004
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823