Literature DB >> 17705790

Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species.

Eric L Bell1, Navdeep S Chandel.   

Abstract

Decreased oxygen availability (hypoxia) promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation and cell viability through the transcription factor HIF (hypoxia-inducible factor). Activation of HIF can also promote pathophysiological processes such as cancer and pulmonary hypertension. The mechanism(s) by which hypoxia activates HIF are the subject of intensive research. In this chapter we outline the model in which mitochondria regulate the stability of HIF through the increased production of ROS (reactive oxygen species) during hypoxia.

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Year:  2007        PMID： 17705790     DOI： 10.1042/BSE0430017

Source DB:  PubMed          Journal:  Essays Biochem        ISSN： 0071-1365            Impact factor:   8.000


  35 in total

1.  Mitigating hypoxic stress on pancreatic islets via in situ oxygen generating biomaterial.

Authors:  Maria M Coronel; Ryan Geusz; Cherie L Stabler
Journal:  Biomaterials       Date:  2017-03-18       Impact factor: 12.479

2.  Transcriptional regulation of yeast oxidative phosphorylation hypoxic genes by oxidative stress.

Authors:  Jingjing Liu; Antoni Barrientos
Journal:  Antioxid Redox Signal       Date:  2012-08-06       Impact factor: 8.401

Review 3.  Redox and reactive oxygen species regulation of mitochondrial cytochrome C oxidase biogenesis.

Authors:  Myriam Bourens; Flavia Fontanesi; Iliana C Soto; Jingjing Liu; Antoni Barrientos
Journal:  Antioxid Redox Signal       Date:  2012-10-15       Impact factor: 8.401

Review 4.  Hypoxia-inducible factors: key regulators of myeloid cells during inflammation.

Authors:  Nan Lin; M Celeste Simon
Journal:  J Clin Invest       Date:  2016-09-06       Impact factor: 14.808

Review 5.  Modulation of oxidative stress as an anticancer strategy.

Authors:  Chiara Gorrini; Isaac S Harris; Tak W Mak
Journal:  Nat Rev Drug Discov       Date:  2013-12       Impact factor: 84.694

Review 6.  Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia.

Authors:  Cristina Carvalho; Sónia C Correia; Renato X Santos; Susana Cardoso; Paula I Moreira; Timothy A Clark; Xiongwei Zhu; Mark A Smith; George Perry
Journal:  J Bioenerg Biomembr       Date:  2009-10       Impact factor: 2.945

7.  MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

Authors:  Elena Favaro; Anassuya Ramachandran; Robert McCormick; Harriet Gee; Christine Blancher; Meredith Crosby; Cecilia Devlin; Christopher Blick; Francesca Buffa; Ji-Liang Li; Borivoj Vojnovic; Ricardo Pires das Neves; Peter Glazer; Francisco Iborra; Mircea Ivan; Jiannis Ragoussis; Adrian L Harris
Journal:  PLoS One       Date:  2010-04-26       Impact factor: 3.240

8.  Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1alpha-induced metabolic reprograming.

Authors:  F Zhao; A Mancuso; T V Bui; X Tong; J J Gruber; C R Swider; P V Sanchez; J J Lum; N Sayed; J V Melo; A E Perl; M Carroll; S W Tuttle; C B Thompson
Journal:  Oncogene       Date:  2010-03-15       Impact factor: 9.867

9.  A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak.

Authors:  David C Irwin; Joe M McCord; Eva Nozik-Grayck; Ginny Beckly; Ben Foreman; Tim Sullivan; Molly White; Joseph T Crossno; Damian Bailey; Sonia C Flores; Susan Majka; Dwight Klemm; Martha C Tissot van Patot
Journal:  Free Radic Biol Med       Date:  2009-04-07       Impact factor: 7.376

Review 10.  Redox regulation of cell survival.

Authors:  Dunyaporn Trachootham; Weiqin Lu; Marcia A Ogasawara; Rivera-Del Valle Nilsa; Peng Huang
Journal:  Antioxid Redox Signal       Date:  2008-08       Impact factor: 8.401
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