| Literature DB >> 17705500 |
Bruce H Lipshutz1, Tom Butler, Asher Lower, Jeff Servesko.
Abstract
Two new "generations" of methodological advances are reported for the Negishi carboalumination of terminal alkynes. Use of simple, inexpensive additives that alter the Al-Zr complex formed between Me(3)Al and Cp(2)ZrCl(2) give rise to an especially effective reagent mix that results in virtually complete control of regiochemistry upon carboalumination of 1-alkynes. One timely application to coenzyme Q10 is highlighted. Regioisomers from subsequent coupling, which would otherwise be very difficult to separate, are avoided.Entities:
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Year: 2007 PMID： 17705500 DOI： 10.1021/ol701469e
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005