Literature DB >> 1770380

The structure-activity relationship of inhibitors of serotonin uptake and receptor binding.

C Hansch1, J Caldwell.   

Abstract

An analysis of five different datasets of inhibitors of serotonin uptake has yielded quantitative structure/activity relationships (QSARs) which delineate the role of steric and hydrophobic properties essential for inhibition by phenylethylamine-type analogues.

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Year:  1991        PMID： 1770380     DOI： 10.1007/bf00125664

Source DB:  PubMed          Journal:  J Comput Aided Mol Des        ISSN： 0920-654X            Impact factor:   3.686


  8 in total

1.  Structure-activity relationships of antineoplastic agents in multidrug resistance.

Authors:  C D Selassie; C Hansch; T A Khwaja
Journal:  J Med Chem       Date:  1990-07       Impact factor: 7.446

2.  Inhibition of human platelet 5-hydroxytryptamine uptake by beta-phenethylamine derivatives.

Authors:  A Richter; S E Smith
Journal:  J Pharm Pharmacol       Date:  1974-10       Impact factor: 3.765

3.  Structural relationships in the inhibition of [3H]tryptamine binding to rat brain membranes in vitro by phenylalkylamines.

Authors:  L L Martin; D M Roland; R F Neale; P L Wood
Journal:  Eur J Pharmacol       Date:  1986-12-02       Impact factor: 4.432

4.  Comparison of triazines as inhibitors of L1210 dihydrofolate reductase and of L1210 cells sensitive and resistant to methotrexate.

Authors:  C D Selassie; C D Strong; C Hansch; T J Delcamp; J H Freisheim; T A Khwaja
Journal:  Cancer Res       Date:  1986-02       Impact factor: 12.701

5.  Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.

Authors:  R A Glennon; R Young; F Benington; R D Morin
Journal:  J Med Chem       Date:  1982-10       Impact factor: 7.446

6.  Molecular determinants for recognition of RU 24969 analogs at central 5-hydroxytryptamine recognition sites: use of a bilinear function and substituent volumes to describe steric fit.

Authors:  E W Taylor; S S Nikam; G Lambert; A R Martin; D L Nelson
Journal:  Mol Pharmacol       Date:  1988-07       Impact factor: 4.436

7.  Quantitative structure-activity relationship of antifolate inhibition of bacteria cell cultures resistant and sensitive to methotrexate.

Authors:  E A Coats; C S Genther; C D Selassie; C D Strong; C Hansch
Journal:  J Med Chem       Date:  1985-12       Impact factor: 7.446

8.  Synthesis of pyridylallylamines related to zimelidine and their inhibition of neuronal monoamine uptake.

Authors:  T Högberg; B Ulff; A L Renyi; S B Ross
Journal:  J Med Chem       Date:  1981-12       Impact factor: 7.446
  8 in total

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