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Literature DB >> 177037

Studies on the relationship between concanavalin A and SV40-transformed human fibroblasts.

Abstract

The extent of binding of 125I-Con A to the surface of SV40-transformed human fibroblasts and the degree of agglutination of the cells by the native lectin have been measured. In addition, trypsinized and succinylated Con A have been used to study the effects of the lectin upon certain cell growth parameters. Trypsinized Con A was found to alter the growth rate, the saturation density and the contact inhibition of the transformed cells, an effect not neutralized by alph-methyl-D-mannoside.

Entities: Chemical Species

Mesh：

Substances：
Mannosides
Concanavalin A

Year: 1976 PMID： 177037 PMCID： PMC2024949 DOI： 10.1038/bjc.1976.28

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

24 in total

1. Receptor sites for concanavalin A on human peripheral lymphocytes and on lymphoblasts grown in long-term culture.

Authors: L De Salle; N Munakata; R M Pauli; B S Strauss
Journal: Cancer Res Date: 1972-11 Impact factor: 12.701

2. Differences in the binding of fluorescent concanavalin A to the surface membrane of normal and transformed cells.

Authors: J Shoham; L Sachs
Journal: Proc Natl Acad Sci U S A Date: 1972-09 Impact factor: 11.205

3. Membrane changes associated with malignancy.

Authors: M Inbar; H Ben-Bassat; L Sachs
Journal: Nat New Biol Date: 1972-03-01

4. Binding of radioactively labelled concanavalin A and wheat germ agglutinin to normal and virus-transformed cells.

Authors: B Ozanne; J Sambrook
Journal: Nat New Biol Date: 1971-08-04

5. Lack of correlation between conversion of RNA tumour viruses and increased agglutinability of cells by concanavalin A and wheat germ agglutinin.

Authors: E G Moore; H M Temin
Journal: Nature Date: 1971-05-14 Impact factor: 49.962

6. Binding of 3 H-concanavalin A by normal and transformed cells.

Authors: M J Cline; D C Livingston
Journal: Nat New Biol Date: 1971-08-04

7. Surface-specific characteristics of a contact-inhibited cell line containing the SV40 viral genome.

Authors: R E Pollack; M M Burger
Journal: Proc Natl Acad Sci U S A Date: 1969-04 Impact factor: 11.205

8. Cell density-dependent changes of glycolipid concentrations in fibroblasts, and loss of this response in virus-transformed cells.

Authors: S Hakomori
Journal: Proc Natl Acad Sci U S A Date: 1970-12 Impact factor: 11.205

Studies on the relationship between concanavalin A and SV40-transformed human fibroblasts.

1. Receptor sites for concanavalin A on human peripheral lymphocytes and on lymphoblasts grown in long-term culture.

2. Differences in the binding of fluorescent concanavalin A to the surface membrane of normal and transformed cells.

3. Membrane changes associated with malignancy.

4. Binding of radioactively labelled concanavalin A and wheat germ agglutinin to normal and virus-transformed cells.

5. Lack of correlation between conversion of RNA tumour viruses and increased agglutinability of cells by concanavalin A and wheat germ agglutinin.

6. Binding of 3 H-concanavalin A by normal and transformed cells.

7. Surface-specific characteristics of a contact-inhibited cell line containing the SV40 viral genome.

8. Cell density-dependent changes of glycolipid concentrations in fibroblasts, and loss of this response in virus-transformed cells.

9. Interaction of the carbohydrate-binding protein concanavalin A with normal and transformed cells.

10. The fluid mosaic model of the structure of cell membranes.

Review 1. Human cell transformation by simian virus 40--a review.

2. Sulphated acid mucopolysaccharides in SV40-transformed human cells from normal and mucopolysaccharidosis patients.