Giant cell carcinoma of the lung impact of diagnosis and review of cytological features.

Giant cell carcinoma of the lung is a specific type of lung carcinoma characteristically associated with a highly aggressive clinical behavior. This tumor comprises approximately 1-5% of all lung cancers, affecting a similar patient population as other primary pulmonary carcinomas. It is not routinely treated surgically, owing to the fact that it is metastatic at the time of diagnosis. The cytological diagnosis of this entity on aspiration biopsy has an appreciable impact on patient care. We retrospectively examined 15 cases of lung fine-needle aspirates in which a diagnosis of giant cell carcinoma or large cell carcinoma with giant cell features was made. We applied the criteria for cytological diagnosis of giant cell carcinoma previously set forth in the literature. In cases where there is a tissue diagnosis, we compared the results with the corresponding fine-needle aspirates and correlated them with patient survival. Conclusions are made regarding the reliability of the diagnostic criteria of this malignancy. (c) 2007 Wiley-Liss, Inc.