OBJECTIVE: We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions. METHOD: We studied 217 older depressed patients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject. RESULTS: In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressed patients. This relationship lost significance in models controlling for reported hypertension. CONCLUSIONS: The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to development of hypertension.
OBJECTIVE: We examined the relationship between 5HTTLPR genotype and volume of magnetic resonance imaging (MRI) brain lesions. METHOD: We studied 217 older depressedpatients and 141 individuals in the comparison group using a standard brain MRI protocol to calculate lesion volumes. Genotype at 5HTTLPR was determined for each subject. RESULTS: In age-adjusted models, the l/s genotype was associated with increased volume of total and white-matter lesions among depressedpatients. This relationship lost significance in models controlling for reported hypertension. CONCLUSIONS: The finding that 5HTTLPR heterozygotes have higher vascular lesion volumes may be related to development of hypertension.
Authors: Eric J Lenze; Michelle Shardell; Robert E Ferrell; Denise Orwig; Janet Yu-Yahiro; William Hawkes; Lisa Fredman; Ram Miller; Jay Magaziner Journal: J Affect Disord Date: 2008-03-11 Impact factor: 4.839
Authors: George S Alexopoulos; Christopher F Murphy; Faith M Gunning-Dixon; Charles E Glatt; Vassilios Latoussakis; Robert E Kelly; Dora Kanellopoulos; Sibel Klimstra; Kelvin O Lim; Robert C Young; Matthew J Hoptman Journal: J Affect Disord Date: 2009-04-17 Impact factor: 4.839
Authors: Diego A Ojeda; Claudia S Perea; Annjy Suárez; Carmen L Niño; Rafael M Gutiérrez; Sandra López-León; Ana Adan; Humberto Arboleda; Andrés Camargo; Diego A Forero Journal: Neurol Sci Date: 2013-06-01 Impact factor: 3.307
Authors: Edmund J S Sonuga-Barke; Robert Kumsta; Wolff Schlotz; Jessica Lasky-Su; Rafaela Marco; Ana Miranda; Fernando Mulas; Robert D Oades; Tobias Banaschewski; Ueli Mueller; Penny Andreou; Hanna Christiansen; Isabel Gabriels; Henrik Uebel; Jonna Kuntsi; Barbara Franke; Jan Buitelaar; Richard Ebstein; Michael Gill; Richard Anney; Herbert Roeyers; Aribert Rothenberger; Joseph Sergeant; Hans Christoph Steinhausen; Philip Asherson; Stephen V Faraone Journal: Biol Psychiatry Date: 2011-04-17 Impact factor: 13.382