Synthesis, characterization, and evaluation of phosphated cross-linked konjac glucomannan hydrogels for colon-targeted drug delivery.

Hydrogel systems of konjac glucomannan (KGM) cross-linked with trisodium trimetaphosphate (STMP) were prepared for colon-targeting drug delivery. Swelling degrees of the hydrogels were measured in artificial gastrointestinal fluids and in sodium chloride solution with different concentrations to study their dependence on the cross-linking density and the ionic strength. The absorption of methylene blue was used to characterize the degree of the KGM cross-linking. In vitro release of model drug hydrocortisone was studied in presence and absence of beta -mannanase. KGM cross-linked with STMP was able to retard the release of the poorly water-soluble drug and could be biodegraded enzymatically. Hydrocortisone release was cross-linking density dependent and controlled by degradation of the hydrogles.