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Literature DB >> 17701292

Preparation and characterization of magnetic poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) microspheres.

Ma Ling Gou¹, Zhi Yong Qian, Hui Wang, Yong Bo Tang, Mei Juan Huang, Bing Kan, Yan Juan Wen, Mei Dai, Xing Yi Li, Chang Yang Gong, Ming Jing Tu.

Abstract

In this article, nano-magnetite particles (ferrofluid, Fe3O4) were prepared by chemical co-deposition method. A series of biodegradable triblock poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL, PCEC) copolymers were synthesized by ring-opening polymerization method from epsilon-caprolactone (epsilon-CL) initiated by poly(ethylene glycol) diol (PEG) using stannous octoate as catalyst. And the magnetic PCEC composite microspheres were prepared by solvent diffusion method. The properties of the ferrofluid, PCEC copolymer, and magnetic PCEC microspheres were studied in detail by SEM, VSM, XRD, Malvern Laser Particle Sizer, 1H-NMR, GPC, and TG/DTG. Effects of macromolecular weight and concentration of polymer, and the time for ultrasound dispersion on properties of magnetic microspheres were also investigated. The obtained magnetic PCEC microspheres might have great potential application in targeted drug delivery system or cell separation.

Entities: Chemical

Mesh：

Substances：

Year: 2007 PMID： 17701292 DOI： 10.1007/s10856-007-3230-3

Source DB: PubMed Journal: J Mater Sci Mater Med ISSN： 0957-4530 Impact factor: 3.896

9 in total

1. The use of coated paramagnetic particles as a physical label in a magneto-immunoassay.

Authors: J Richardson; P Hawkins; R Luxton
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2. Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC).

Authors: S Rudge; C Peterson; C Vessely; J Koda; S Stevens; L Catterall
Journal: J Control Release Date: 2001-07-06 Impact factor: 9.776

3. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method.

Authors: Y Y Yang; H H Chia; T S Chung
Journal: J Control Release Date: 2000-10-03 Impact factor: 9.776

4. Ultrasonically controlled release and targeted delivery of diclofenac sodium via gelatin magnetic microspheres.

Authors: Muniyandy Saravanan; Kesavan Bhaskar; Gomathinayagam Maharajan; Kalathil Sadasivan Pillai
Journal: Int J Pharm Date: 2004-09-28 Impact factor: 5.875

5. Ferrite supports for isolation of DNA from complex samples and polymerase chain reaction amplification.

Authors: Alena Spanová; Bohuslav Rittich; Milan J Benes; Daniel Horák
Journal: J Chromatogr A Date: 2005-07-01 Impact factor: 4.759

6. A novel formulation design about water-insoluble oily drug: preparation of zedoary turmeric oil microspheres with self-emulsifying ability and evaluation in rabbits.

Authors: Jian You; Fu-de Cui; Qing-Po Li; Xu Han; Ying-Wei Yu; Ming-Shi Yang
Journal: Int J Pharm Date: 2004-12-08 Impact factor: 5.875

7. Mucoadhesive microspheres prepared by interpolymer complexation and solvent diffusion method.

Authors: Myung-Kwan Chun; Chong-Su Cho; Hoo-Kyun Choi
Journal: Int J Pharm Date: 2004-12-15 Impact factor: 5.875

8. Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-L-proline).

Authors: Zhenhua Li; Leaf Huang
Journal: J Control Release Date: 2004-08-27 Impact factor: 9.776

9. Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system.

Authors: Shaobing Zhou; Xianmo Deng; Hua Yang
Journal: Biomaterials Date: 2003-09 Impact factor: 12.479

9 in total

6 in total

1. Supercritical synthesis of poly (2-dimethylaminoethyl methacrylate)/ferrite nanocomposites for real-time monitoring of protein release.

Authors: Gunjan Bisht; M G H Zaidi
Journal: Drug Deliv Transl Res Date: 2015-06 Impact factor: 4.617

Preparation and characterization of magnetic poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) microspheres.

1. The use of coated paramagnetic particles as a physical label in a magneto-immunoassay.

2. Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier (MTC).

3. Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres containing protein fabricated by double-emulsion solvent extraction/evaporation method.

4. Ultrasonically controlled release and targeted delivery of diclofenac sodium via gelatin magnetic microspheres.

5. Ferrite supports for isolation of DNA from complex samples and polymerase chain reaction amplification.

6. A novel formulation design about water-insoluble oily drug: preparation of zedoary turmeric oil microspheres with self-emulsifying ability and evaluation in rabbits.

7. Mucoadhesive microspheres prepared by interpolymer complexation and solvent diffusion method.

8. Sustained delivery and expression of plasmid DNA based on biodegradable polyester, poly(D,L-lactide-co-4-hydroxy-L-proline).

9. Biodegradable poly(epsilon-caprolactone)-poly(ethylene glycol) block copolymers: characterization and their use as drug carriers for a controlled delivery system.

1. Supercritical synthesis of poly (2-dimethylaminoethyl methacrylate)/ferrite nanocomposites for real-time monitoring of protein release.

2. Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent.

Review 3. Regulation of the matrix microenvironment for stem cell engineering and regenerative medicine.

4. PEG-functionalized magnetic nanoparticles for drug delivery and magnetic resonance imaging applications.

5. A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers.

Review 6. Multifunctional and stimuli-sensitive pharmaceutical nanocarriers.