Kumiko Nakao1, Yuka Shimonagano, Norihito Doi, Taiji Sakamoto. 1. Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. nakao@m2.kufm.kagoshima-u.ac.jp
Abstract
BACKGROUND: To report on conjunctival nodules as an unusual manifestation of Vogt-Koyanagi-Harada disease. METHODS: A 24-year-old woman presented with a two-month history of bilateral conjunctival injection and gradually decreased vision. Ophthalmological examinations revealed bilateral granulomatous uveitis and bulbar conjunctival nodules, and a biopsy of the conjunctival nodules was performed. RESULTS: The biopsy specimens showed noncaseating granulomas. The major components of the infiltrating lymphocytes were CD8-positive T cells. Topical corticosteroid therapy reduced the anterior segment inflammation, and the conjunctival nodules disappeared within a week. Afterwards, the patient demonstrated bilateral retinal detachments, sunset glow fundus and alopecia, and, therefore, was diagnosed to have Vogt-Koyanagi-Harada disease four months after the first symptoms. CONCLUSIONS: Conjunctival nodules may represent the primary manifestation of Vogt-Koyanagi-Harada disease.
BACKGROUND: To report on conjunctival nodules as an unusual manifestation of Vogt-Koyanagi-Harada disease. METHODS: A 24-year-old woman presented with a two-month history of bilateral conjunctival injection and gradually decreased vision. Ophthalmological examinations revealed bilateral granulomatous uveitis and bulbar conjunctival nodules, and a biopsy of the conjunctival nodules was performed. RESULTS: The biopsy specimens showed noncaseating granulomas. The major components of the infiltrating lymphocytes were CD8-positive T cells. Topical corticosteroid therapy reduced the anterior segment inflammation, and the conjunctival nodules disappeared within a week. Afterwards, the patient demonstrated bilateral retinal detachments, sunset glow fundus and alopecia, and, therefore, was diagnosed to have Vogt-Koyanagi-Harada disease four months after the first symptoms. CONCLUSIONS: Conjunctival nodules may represent the primary manifestation of Vogt-Koyanagi-Harada disease.
Authors: R W Read; G N Holland; N A Rao; K F Tabbara; S Ohno; L Arellanes-Garcia; P Pivetti-Pezzi; H H Tessler; M Usui Journal: Am J Ophthalmol Date: 2001-05 Impact factor: 5.258
Authors: C C Chan; D Benezra; M M Rodrigues; A G Palestine; S M Hsu; A L Murphree; R B Nussenblatt Journal: Ophthalmology Date: 1985-04 Impact factor: 12.079