Literature DB >> 17700621

Merkel cell carcinoma: more deaths but still no pathway to blame.

Bianca Lemos1, Paul Nghiem.   

Abstract

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer with a rising incidence (1500 U.S. cases per year) that now exceeds that of cutaneous T-cell lymphoma and a mortality (33%) exceeding that of melanoma. Despite this impact, little is known about its biology. Recent studies have shown that Ras/MAP kinase activity is absent and possibly detrimental to this cancer. This makes MCC distinct from other UV--induced skin cancers and highlights the question of what drives this malignancy.

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Year:  2007        PMID： 17700621     DOI： 10.1038/sj.jid.5700925

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  78 in total

1.  Therapeutic options for treatment of Merkel cell carcinoma.

Authors:  Kathrin Gessner; Gunnar Wichmann; Andreas Boehm; Anett Reiche; Julia Bertolini; Johannes Brus; Ina Sterker; Stefan Dietzsch; Andreas Dietz
Journal:  Eur Arch Otorhinolaryngol       Date:  2010-08-27       Impact factor: 2.503

Review 2.  Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer.

Authors:  Shailender Bhatia; Olga Afanasiev; Paul Nghiem
Journal:  Curr Oncol Rep       Date:  2011-12       Impact factor: 5.075

3.  Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system.

Authors:  Bianca D Lemos; Barry E Storer; Jayasri G Iyer; Jerri Linn Phillips; Christopher K Bichakjian; L Christine Fang; Timothy M Johnson; Nanette J Liegeois-Kwon; Clark C Otley; Kelly G Paulson; Merrick I Ross; Siegrid S Yu; Nathalie C Zeitouni; David R Byrd; Vernon K Sondak; Jeffrey E Gershenwald; Arthur J Sober; Paul Nghiem
Journal:  J Am Acad Dermatol       Date:  2010-06-19       Impact factor: 11.527

4.  Merkel cell carcinoma of unknown primary origin.

Authors:  Jeremiah L Deneve; Jane L Messina; Suroosh S Marzban; Ricardo J Gonzalez; Brooke M Walls; Kate J Fisher; Y Ann Chen; C Wayne Cruse; Vernon K Sondak; Jonathan S Zager
Journal:  Ann Surg Oncol       Date:  2012-01-21       Impact factor: 5.344

Review 5.  Merkel Cell Carcinoma in the Age of Immunotherapy: Facts and Hopes.

Authors:  Aric Colunga; Thomas Pulliam; Paul Nghiem
Journal:  Clin Cancer Res       Date:  2017-12-07       Impact factor: 12.531

6.  Getting stronger: the relationship between a newly identified virus and Merkel cell carcinoma.

Authors:  Christopher B Buck; Douglas R Lowy
Journal:  J Invest Dermatol       Date:  2009-01       Impact factor: 8.551

7.  Phosphorylation of Merkel cell polyomavirus large tumor antigen at serine 816 by ATM kinase induces apoptosis in host cells.

Authors:  Jing Li; Jason Diaz; Xin Wang; Sabrina H Tsang; Jianxin You
Journal:  J Biol Chem       Date:  2014-12-05       Impact factor: 5.157

Review 8.  Merkel cell polyomavirus infection and Merkel cell carcinoma.

Authors:  Wei Liu; Margo MacDonald; Jianxin You
Journal:  Curr Opin Virol       Date:  2016-08-10       Impact factor: 7.090

9.  Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma.

Authors:  Maryam M Asgari; Monica M Sokil; E Margaret Warton; Jayasri Iyer; Kelly G Paulson; Paul Nghiem
Journal:  JAMA Dermatol       Date:  2014-07       Impact factor: 10.282

10.  Merkel cell polyomavirus expression in merkel cell carcinomas and its absence in combined tumors and pulmonary neuroendocrine carcinomas.

Authors:  Klaus J Busam; Achim A Jungbluth; Natasha Rekthman; Daniel Coit; Melissa Pulitzer; Jason Bini; Reety Arora; Nicole C Hanson; Jodie A Tassello; Denise Frosina; Patrick Moore; Yuan Chang
Journal:  Am J Surg Pathol       Date:  2009-09       Impact factor: 6.394
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