PURPOSE: To assess the gadolinium-based macromolecular intravascular contrast agent P792 for magnetic resonance angiography (MRA) at magnetic field strengths of 3.0 T, in comparison to 1.5 T, in rabbits. MATERIALS AND METHODS: Eleven female New Zealand rabbits of the same age served as the animal model. Dose relationship testing was performed with 2 doses (13 and 25 micromol/kg; n = 4 per group) of P792 as compared with a single dose (100 micromol/kg; n = 3) of gadoterate meglumine (Gd-DOTA). All animals underwent contrast-enhanced MRA of the abdominal aorta and its branches on 2 occasions separated by 72 hours. The particular doses were administered in random order. Contrast-enhanced MRA was performed on 3.0 and 1.5 T whole-body MR systems, using a fast 3D spoiled gradient recalled echo sequence. Data acquisition was performed before and up to 10 minutes after administration of intravenous contrast material. Image quality was judged on a 4-point-Likert scale. Signal-to-noise and contrast-to-noise measurements were performed; statistical differences (P < 0.05) between the groups were determined. RESULTS: P792 and Gd-DOTA yielded high-quality MR angiograms in rabbits in all cases. Although image quality within the first 3 minutes after contrast material administration was equal for both agents, P792 at a dose of 25 micromol/kg was considered superior to Gd-DOTA at the later time points. Signal-to-noise and contrast-to-noise values of the higher dose of P792 were statistically significantly higher than those of Gd-DOTA in the post-bolus phase. CONCLUSIONS: P792 seems to be well suited for high-quality early phase and equilibrium phase MRA in rabbits at a field strength of 3.0 T, on the basis of this initial evaluation in an animal model.
PURPOSE: To assess the gadolinium-based macromolecular intravascular contrast agent P792 for magnetic resonance angiography (MRA) at magnetic field strengths of 3.0 T, in comparison to 1.5 T, in rabbits. MATERIALS AND METHODS: Eleven female New Zealand rabbits of the same age served as the animal model. Dose relationship testing was performed with 2 doses (13 and 25 micromol/kg; n = 4 per group) of P792 as compared with a single dose (100 micromol/kg; n = 3) of gadoterate meglumine (Gd-DOTA). All animals underwent contrast-enhanced MRA of the abdominal aorta and its branches on 2 occasions separated by 72 hours. The particular doses were administered in random order. Contrast-enhanced MRA was performed on 3.0 and 1.5 T whole-body MR systems, using a fast 3D spoiled gradient recalled echo sequence. Data acquisition was performed before and up to 10 minutes after administration of intravenous contrast material. Image quality was judged on a 4-point-Likert scale. Signal-to-noise and contrast-to-noise measurements were performed; statistical differences (P < 0.05) between the groups were determined. RESULTS: P792 and Gd-DOTA yielded high-quality MR angiograms in rabbits in all cases. Although image quality within the first 3 minutes after contrast material administration was equal for both agents, P792 at a dose of 25 micromol/kg was considered superior to Gd-DOTA at the later time points. Signal-to-noise and contrast-to-noise values of the higher dose of P792 were statistically significantly higher than those of Gd-DOTA in the post-bolus phase. CONCLUSIONS: P792 seems to be well suited for high-quality early phase and equilibrium phase MRA in rabbits at a field strength of 3.0 T, on the basis of this initial evaluation in an animal model.
Authors: Heejung Kim; Sung-Jin Lee; Cynthia Davies-Venn; Jin Su Kim; Bo Yeun Yang; Zhengsheng Yao; Insook Kim; Chang H Paik; David A Bluemke Journal: Nucl Med Commun Date: 2016-02 Impact factor: 1.690
Authors: Mark Woods; Peter Caravan; Carlos F G C Geraldes; Matthew T Greenfield; Garry E Kiefer; Mai Lin; Kenneth McMillan; M Isabel M Prata; Ana C Santos; Xiankai Sun; Jufeng Wang; Shanrong Zhang; Piyu Zhao; A Dean Sherry Journal: Invest Radiol Date: 2008-12 Impact factor: 6.016