OBJECTIVE: Electroacupuncture (EA) has been used to treat myalgia, allergy and gastroenteropathy in Korea. To determine whether EA can treat anaphylactic and inflammatory reactions, the effect of EA was investigated in a murine model. METHODS: EA stimulation of the ST36 acupoint was performed for 10 min. Using a passive cutaneous anaphylaxis (PCA) model, the antianaphylactic effects of EA were examined. Interleukin-6 and tumor necrosis factor-alpha were measured using the ELISA method. The level of nuclear factor (NF)-kappaB/RelA protein and NF-kappaB DNA-binding activity was determined using the Western blot analysis and the transcription factor enzyme-linked immunoassay method. RESULTS: EA inhibits PCA and beta-hexosaminidase release, IL-6 secretion on the PCA, and in addition, EA reduces NF-kappaB DNA-binding activity. CONCLUSION: These results indicate that EA may possess antianaphylactic and antiinflammatory properties. Copyright 2007 S. Karger AG, Basel.
OBJECTIVE: Electroacupuncture (EA) has been used to treat myalgia, allergy and gastroenteropathy in Korea. To determine whether EA can treat anaphylactic and inflammatory reactions, the effect of EA was investigated in a murine model. METHODS: EA stimulation of the ST36 acupoint was performed for 10 min. Using a passive cutaneous anaphylaxis (PCA) model, the antianaphylactic effects of EA were examined. Interleukin-6 and tumor necrosis factor-alpha were measured using the ELISA method. The level of nuclear factor (NF)-kappaB/RelA protein and NF-kappaB DNA-binding activity was determined using the Western blot analysis and the transcription factor enzyme-linked immunoassay method. RESULTS: EA inhibits PCA and beta-hexosaminidase release, IL-6 secretion on the PCA, and in addition, EA reduces NF-kappaB DNA-binding activity. CONCLUSION: These results indicate that EA may possess antianaphylactic and antiinflammatory properties. Copyright 2007 S. Karger AG, Basel.
Authors: E Anne Lown; Anu Banerjee; Eric Vittinghoff; Christopher C Dvorak; Wendy Hartogensis; Alexis Melton; Christina Mangurian; Hiroe Hu; Deborah Shear; Robyn Adcock; Michael Morgan; Carla Golden; Frederick M Hecht Journal: Glob Adv Health Med Date: 2019-08-14
Authors: Albino Villegas-Bastida; Rafael Torres-Rosas; Lourdes Andrea Arriaga-Pizano; Javier Flores-Estrada; Altamirano Gustavo-Acosta; Mario Adan Moreno-Eutimio Journal: Evid Based Complement Alternat Med Date: 2014-06-26 Impact factor: 2.629