Barbara E K Klein1, Kristine E Lee, Ronald Klein. 1. Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisc., USA. kleinb@epi.ophth.wisc.edu
Abstract
OBJECTIVE: Long-lived persons tend to share a survival advantage with their parents and siblings; however, there is limited information on benefit beyond the extremes of longevity. We evaluated a survival benefit associated with age of parents. METHODS: A population-based study of adults 43-86 years of age in a Midwestern town was performed (n = 4,926). Extensive exam and questionnaire information including current age or age at death of parents of study participants was obtained. RESULTS: While adjusting for age and gender, those with at least one parent surviving to 100 years of age had the best survival (92% survive to age 70 and 54% to age 90). There appeared to be a survival benefit for each decade of maximal parental age. A trend persists when additional risk factors are included in the model. DISCUSSION: There is a survival benefit to offspring of increasing parental age that is apparent as early as 80 years of parental age. Copyright 2007 S. Karger AG, Basel.
OBJECTIVE: Long-lived persons tend to share a survival advantage with their parents and siblings; however, there is limited information on benefit beyond the extremes of longevity. We evaluated a survival benefit associated with age of parents. METHODS: A population-based study of adults 43-86 years of age in a Midwestern town was performed (n = 4,926). Extensive exam and questionnaire information including current age or age at death of parents of study participants was obtained. RESULTS: While adjusting for age and gender, those with at least one parent surviving to 100 years of age had the best survival (92% survive to age 70 and 54% to age 90). There appeared to be a survival benefit for each decade of maximal parental age. A trend persists when additional risk factors are included in the model. DISCUSSION: There is a survival benefit to offspring of increasing parental age that is apparent as early as 80 years of parental age. Copyright 2007 S. Karger AG, Basel.
Authors: Ambarish Dutta; William Henley; Jean-Marie Robine; Kenneth M Langa; Robert B Wallace; David Melzer Journal: J Gerontol A Biol Sci Med Sci Date: 2013-05-16 Impact factor: 6.053