BACKGROUND: This study aims to detect the impact of stroke on the occurrence of dementia and cognitive impairment/no dementia (CIND) in different age, sex, and education groups. METHODS: Persons with dementia (DSM-III-R) or CIND were identified by a two-phase study design among 7,930 persons from the population-based Faenza Community Aging Study. RESULTS: Subjects with a history of stroke had increased risk of both dementia [risk ratio (RR) = 3.7; 95% confidence interval (CI) = 3.1-4.4] and CIND (RR = 1.7, 95% CI = 1.4-2.2). These associations were stronger in the younger-old (61-74 years) than in the older-old (75+ years), and among higher-educated (4+ years) than lower-educated (0-3 years of schooling) persons. Dementia and CIND prevalence among stroke subjects was similar to the prevalence detected among subjects 10 years older but without a history of stroke. In stroke subjects, dementia prevalence became higher than CIND prevalence 10 years earlier than in non-stroke subjects. A combined effect for dementia due to a history of stroke, increasing age, and decreasing years of schooling was detected. CONCLUSIONS: Stroke is a strong risk factor for dementia among younger-old and higher-educated subjects; in the presence of a stroke, dementia onset might occur about 10 years earlier, possibly by accelerating the progression from CIND to dementia.
BACKGROUND: This study aims to detect the impact of stroke on the occurrence of dementia and cognitive impairment/no dementia (CIND) in different age, sex, and education groups. METHODS:Persons with dementia (DSM-III-R) or CIND were identified by a two-phase study design among 7,930 persons from the population-based Faenza Community Aging Study. RESULTS: Subjects with a history of stroke had increased risk of both dementia [risk ratio (RR) = 3.7; 95% confidence interval (CI) = 3.1-4.4] and CIND (RR = 1.7, 95% CI = 1.4-2.2). These associations were stronger in the younger-old (61-74 years) than in the older-old (75+ years), and among higher-educated (4+ years) than lower-educated (0-3 years of schooling) persons. Dementia and CIND prevalence among stroke subjects was similar to the prevalence detected among subjects 10 years older but without a history of stroke. In stroke subjects, dementia prevalence became higher than CIND prevalence 10 years earlier than in non-stroke subjects. A combined effect for dementia due to a history of stroke, increasing age, and decreasing years of schooling was detected. CONCLUSIONS:Stroke is a strong risk factor for dementia among younger-old and higher-educated subjects; in the presence of a stroke, dementia onset might occur about 10 years earlier, possibly by accelerating the progression from CIND to dementia.
Authors: Matthew E Peters; Paul B Rosenberg; Martin Steinberg; JoAnn T Tschanz; Maria C Norton; Kathleen A Welsh-Bohmer; Kathleen M Hayden; John C S Breitner; Constantine G Lyketsos Journal: Am J Geriatr Psychiatry Date: 2012-05 Impact factor: 4.105
Authors: M E Peters; P B Rosenberg; M Steinberg; M C Norton; K A Welsh-Bohmer; K M Hayden; J Breitner; J T Tschanz; C G Lyketsos Journal: Am J Geriatr Psychiatry Date: 2013-02-06 Impact factor: 4.105
Authors: Peter van Vliet; Behnam Sabayan; Liselotte W Wijsman; Rosalinde K E Poortvliet; Simon P Mooijaart; Wouter de Ruijter; Jacobijn Gussekloo; Anton J M de Craen; R G J Westendorp Journal: Neurology Date: 2014-08-20 Impact factor: 9.910
Authors: Ronald C Petersen; Oscar Lopez; Melissa J Armstrong; Thomas S D Getchius; Mary Ganguli; David Gloss; Gary S Gronseth; Daniel Marson; Tamara Pringsheim; Gregory S Day; Mark Sager; James Stevens; Alexander Rae-Grant Journal: Neurology Date: 2017-12-27 Impact factor: 9.910
Authors: D G Clark; A D Boan; C Sims-Robinson; R J Adams; E J Amella; A Benitez; D T Lackland; B Ovbiagele Journal: J Stroke Cerebrovasc Dis Date: 2018-08-01 Impact factor: 2.136