Literature DB >> 17699831

Toll-like receptor 4 polymorphism associated with the response to whole-cell pertussis vaccination in children from the KOALA study.

Sander Banus1, Renske W B Bottema, Christine L E Siezen, Rob J Vandebriel, Johan Reimerink, Monique Mommers, Gerard H Koppelman, Barbara Hoebee, Carel Thijs, Dirkje S Postma, Tjeerd G Kimman, Foekje F Stelma.   

Abstract

We examined the association between haplotype tagging single-nucleotide polymorphisms in TLR4 and the pertussis toxin-specific immunoglobulin G response after whole-cell pertussis (wP) vaccination in 515 1-year-old children from the KOALA study. A lower titer was associated with the minor allele of rs2770150, supporting a role for Toll-like receptor 4 in the antibody response to wP vaccination.

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Year:  2007        PMID： 17699831      PMCID： PMC2168111          DOI： 10.1128/CVI.00175-07

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  27 in total

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