| Literature DB >> 17699239 |
Kathryn J Tinckam1, Anil Chandraker.
Abstract
The role of alloantibodies against HLA and non-HLA targets is becoming increasingly recognized as critical in the pathogenesis of acute and chronic renal allograft outcomes. This review discusses the antigenic targets, the mechanisms of T and B cell activation that result in the production of antibody, the complement cascade, methods of antibody detection, and the evidence that alloantibody-mediated mechanisms are active in acute and chronic rejection.Mesh:
Substances:
Year: 2006 PMID: 17699239 DOI: 10.2215/CJN.00270106
Source DB: PubMed Journal: Clin J Am Soc Nephrol ISSN: 1555-9041 Impact factor: 8.237