| Literature DB >> 17698262 |
Richard J Anderson1, Joerg Schneider.
Abstract
Plasmid DNA and viral vector-based cancer vaccines have many inherent features that make them promising cancer vaccine candidates. This review focuses on the use of plasmid DNA and viral vector vaccines to deliver tumour-specific antigens to induce a tumour-specific immune response. Examples of different antigen delivery systems that have been tested in recent clinical trials are summarised and advantages and disadvantages of a number of delivery systems and approaches are discussed. Finally, an outlook on how plasmid DNA and viral vectors might be developed further as cancer vaccines is provided.Entities:
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Year: 2007 PMID: 17698262 DOI: 10.1016/j.vaccine.2007.05.030
Source DB: PubMed Journal: Vaccine ISSN: 0264-410X Impact factor: 3.641