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Literature DB >> 17697639

IL-13 receptor isoforms: breaking through the complexity.

Yasuhiro Tabata¹, Gurjit K Khurana Hershey.

Abstract

Interleukin (IL)-13 is an immunoregulatory cytokine secreted predominantly by activated T-helper type 2 (Th2) cells, and it has been identified as crucial in developing allergic inflammatory responses. Its diverse functions are mediated by a complex receptor system including IL-4 receptor alpha (IL-4Ralpha; CD124) and two other cognate cell surface proteins, IL-13Ralpha1 (CD213a1) and IL-13Ralpha2 (CD213a2). IL-13Ralpha1 forms a heterodimer with IL-4Ralpha that is a signaling IL-13 receptor. In contrast, IL-13Ralpha2 has been thought to be a decoy receptor due to its short cytoplasmic tail. IL-13Ralpha2 exists on the cell membrane, intracellularly, and in soluble form. Recent reports revealed that membrane IL-13Ralpha2 may have some signaling capabilities, and soluble IL-13Ralpha2 is a critical endogenous modulator for IL-13 responses. The receptor has more complicated functions than a simple decoy receptor. In this review, we describe the isoforms of IL-13Ralpha2 and discuss newly revealed functions of IL-13Ralpha2.

Entities: Gene

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Year: 2007 PMID： 17697639 DOI： 10.1007/s11882-007-0051-x

Source DB: PubMed Journal: Curr Allergy Asthma Rep ISSN： 1529-7322 Impact factor: 4.806

55 in total

1. Allergy-driven alternative splicing of IL-13 receptor alpha2 yields distinct membrane and soluble forms.

Authors: Yasuhiro Tabata; Weiguo Chen; Manoj R Warrier; Aaron M Gibson; Michael O Daines; Gurjit K Khurana Hershey
Journal: J Immunol Date: 2006-12-01 Impact factor: 5.422

2. Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling.

Authors: Michael O Daines; Yasuhiro Tabata; Bradley A Walker; Weiguo Chen; Manoj R Warrier; Saswata Basu; Gurjit K Khurana Hershey
Journal: J Immunol Date: 2006-06-15 Impact factor: 5.422

3. Chromosome mapping and expression of the human interleukin-13 receptor.

Authors: J Guo; F Apiou; M P Mellerin; B Lebeau; Y Jacques; S Minvielle
Journal: Genomics Date: 1997-05-15 Impact factor: 5.736

4. Reconstitution of a functional human type II IL-4/IL-13 receptor in mouse B cells: demonstration of species specificity.

Authors: R Andrews; L Rosa; M Daines; G Khurana Hershey
Journal: J Immunol Date: 2001-02-01 Impact factor: 5.422

5. A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma.

Authors: Michael O Daines; Gurjit K Khurana Hershey
Journal: J Biol Chem Date: 2002-01-10 Impact factor: 5.157

6. IL13RA2 gene polymorphisms are associated with systemic sclerosis.

Authors: Brigitte Granel; Yannick Allanore; Christophe Chevillard; Violaine Arnaud; Sandrine Marquet; Pierre-Jean Weiller; Jean-Marc Durand; Jean-Robert Harlé; Claire Grange; Yves Frances; Philippe Berbis; Jean Gaudart; Philippe de Micco; André Kahan; Alain Dessein
Journal: J Rheumatol Date: 2006-09-15 Impact factor: 4.666

7. Localization of human interleukin 13 receptor in non-haematopoietic cells.

Authors: M Akaiwa; B Yu; R Umeshita-Suyama; N Terada; H Suto; T Koga; K Arima; S Matsushita; H Saito; H Ogawa; M Furue; N Hamasaki; K Ohshima; K Izuhara
Journal: Cytokine Date: 2001-01-21 Impact factor: 3.861

8. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain.

Authors: D Caput; P Laurent; M Kaghad; J M Lelias; S Lefort; N Vita; P Ferrara
Journal: J Biol Chem Date: 1996-07-12 Impact factor: 5.157

9. Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain.

Authors: Koji Kawakami; Masaki Terabe; Mariko Kawakami; Jay A Berzofsky; Raj K Puri
Journal: Cancer Res Date: 2006-04-15 Impact factor: 12.701

10. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response.

Authors: Monica G Chiaramonte; Margaret Mentink-Kane; Bruce A Jacobson; Allen W Cheever; Matthew J Whitters; Mary E P Goad; Anthony Wong; Mary Collins; Debra D Donaldson; Michael J Grusby; Thomas A Wynn
Journal: J Exp Med Date: 2003-03-17 Impact factor: 14.307

35 in total

Review 1. The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations.

Authors: Eleanor M Dunican; John V Fahy
Journal: Ann Am Thorac Soc Date: 2015-11

2. Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state.

Authors: Ke Zen; Yalan Guo; Zhen Bian; Zhiyuan Lv; Dihan Zhu; Hiroshi Ohnishi; Takashi Matozaki; Yuan Liu
Journal: Nat Commun Date: 2013 Impact factor: 14.919

3. From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders.

Authors: Ariel F Martinez; Maximilian Muenke; Mauricio Arcos-Burgos
Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2010-11-12 Impact factor: 3.568

IL-13 receptor isoforms: breaking through the complexity.

1. Allergy-driven alternative splicing of IL-13 receptor alpha2 yields distinct membrane and soluble forms.

2. Level of expression of IL-13R alpha 2 impacts receptor distribution and IL-13 signaling.

3. Chromosome mapping and expression of the human interleukin-13 receptor.

4. Reconstitution of a functional human type II IL-4/IL-13 receptor in mouse B cells: demonstration of species specificity.

5. A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma.

6. IL13RA2 gene polymorphisms are associated with systemic sclerosis.

7. Localization of human interleukin 13 receptor in non-haematopoietic cells.

8. Cloning and characterization of a specific interleukin (IL)-13 binding protein structurally related to the IL-5 receptor alpha chain.

9. Characterization of a novel human tumor antigen interleukin-13 receptor alpha2 chain.

10. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response.

Review 1. The Role of Type 2 Inflammation in the Pathogenesis of Asthma Exacerbations.

2. Inflammation-induced proteolytic processing of the SIRPα cytoplasmic ITIM in neutrophils propagates a proinflammatory state.

3. From the black widow spider to human behavior: Latrophilins, a relatively unknown class of G protein-coupled receptors, are implicated in psychiatric disorders.

4. Matrix metalloproteinase 8 contributes to solubilization of IL-13 receptor alpha2 in vivo.

5. TNF-α/IL-17 synergy inhibits IL-13 bioactivity via IL-13Rα2 induction.

6. IL-17A expression in HIV-specific CD8 T cells is regulated by IL-4/IL-13 following HIV-1 prime-boost immunization.

Review 7. Role of anti-inflammatory cytokines IL-4 and IL-13 in systemic sclerosis.

8. Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation.

Review 9. The immune pathogenesis of scleroderma: context is everything.

10. IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B1 and B2 receptors through a STAT6-dependent mechanism.