| Literature DB >> 17697169 |
Kostas Verdelis1, Lyudmilla Lukashova, Mitsuo Yamauchi, Peter Atsawasuwan, John T Wright, Margaret G E Peterson, Divya Jha, Adele L Boskey.
Abstract
Phosphorylation of the organic matrix proteins of dentin is important for the initiation of mineralization, but its relevance in later mineralization stages is controversial. The objective of this study was to analyze changes in the total matrix phosphate content during dentin development and to identify their origin. Amino acid and total matrix phosphate analyses of microdissected developing mantle and circumpulpal fetal bovine dentin specimens were performed. The amino acid composition showed few changes during mantle and circumpulpal dentin maturation. However, the total matrix phosphate content showed a significant, positive correlation with tissue maturation in both mantle and circumpulpal dentin, with a two- and a three-fold increase, respectively, being observed. The data indicate that changes occur in the pattern of phosphorylation of matrix proteins during dentin maturation, which we suggest may play a functional role in later stages of tooth mineralization.Entities:
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Year: 2007 PMID： 17697169 PMCID： PMC2288704 DOI： 10.1111/j.1600-0722.2007.00463.x
Source DB: PubMed Journal: Eur J Oral Sci ISSN： 0909-8836 Impact factor: 2.612