Literature DB >> 1769696

Genetic control of rat T-cell response to Staphylococcus aureus enterotoxins (SE).

Y Fu1, P A Villas, E P Blankenhorn.   

Abstract

Rat T cells, like those of mouse and human origin, respond strongly to superantigens (SAg) derived from Staphylococcus aureus enterotoxins A and B (SEA, SEB). Lewis and ACI are high responders, whereas Brown Norway (BN) is a low responder. Congenic and back-cross rat studies indicate that the degree of responsiveness is controlled by at least one non-MHC gene. The action of these genes may reside in the antigen-presenting cells (APC), since both Sephadex G10 non-adherent BN spleen cells and purified BN T cells in the presence of Lewis APC can respond well to SE. Responses to concanavalin A (Con A) and SEA generally segregate together in back-cross rats. Surprisingly, the degree of responsiveness to Con A and SEA is not correlated with the susceptibility to experimental allergic encephalomyelitis (EAE) either in independently derived inbred rat strains or in (Lewis x BN) x BN back-cross rats.

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Year:  1991        PMID： 1769696      PMCID： PMC1384644     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  23 in total

Review 1.  The V-region disease hypothesis: evidence from autoimmune encephalomyelitis.

Authors:  E Heber-Katz; H Acha-Orbea
Journal:  Immunol Today       Date:  1989-05

Review 2.  Tolerance to self antigens shapes the T-cell repertoire.

Authors:  A M Pullen; J W Kappler; P Marrack
Journal:  Immunol Rev       Date:  1989-02       Impact factor: 12.988

3.  Stimulation of mouse lymphocytes by a mitogen derived from Mycoplasma arthritidis. VII. Responsiveness is associated with expression of a product(s) of the V beta 8 gene family present on the T cell receptor alpha/beta for antigen.

Authors:  B C Cole; D R Kartchner; D J Wells
Journal:  J Immunol       Date:  1989-06-15       Impact factor: 5.422

4.  Role of non-RT1 genes in the response of rat lymphocytes to Mycoplasma arthritidis T cell mitogen, concanavalin A and phytohemagglutinin.

Authors:  B C Cole; M M Griffiths; G J Sullivan; J R Ward
Journal:  J Immunol       Date:  1986-04-01       Impact factor: 5.422

5.  Genetic control of the in vitro responses of rat peripheral blood lymphocytes to phytohemagglutinin and concanavalin A.

Authors:  C M Newlin; D L Gasser
Journal:  J Immunol       Date:  1973-03       Impact factor: 5.422

6.  Inflammatory mediator-induced hypothalamic-pituitary-adrenal axis activation is defective in streptococcal cell wall arthritis-susceptible Lewis rats.

Authors:  E M Sternberg; J M Hill; G P Chrousos; T Kamilaris; S J Listwak; P W Gold; R L Wilder
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

7.  A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus.

Authors:  Y Choi; J W Kappler; P Marrack
Journal:  Nature       Date:  1991-03-21       Impact factor: 49.962

8.  Toxic-shock-syndrome toxin 1-induced proliferation of lymphocytes: comparison of the mitogenic response of human, murine, and rabbit lymphocytes.

Authors:  N J Poindexter; P M Schlievert
Journal:  J Infect Dis       Date:  1985-01       Impact factor: 5.226

9.  Genetic control of the development of experimental allergic encephalomyelitis in rats. Separation of MHC and non-MHC gene effects.

Authors:  M P Happ; P Wettstein; B Dietzschold; E Heber-Katz
Journal:  J Immunol       Date:  1988-09-01       Impact factor: 5.422

10.  The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice.

Authors:  J White; A Herman; A M Pullen; R Kubo; J W Kappler; P Marrack
Journal:  Cell       Date:  1989-01-13       Impact factor: 41.582
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