Markus Braun-Falco1. 1. Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany. markus.braun-falco@uniklinik-freiburg.de
Abstract
BACKGROUND: The combination of malignant melanoma (MM) and basal cell carcinoma (BCC) within a single tumor is an unusual finding. CASE REPORT: An 84-year-old white man with a pigmented tumor on the back showing a combination of MM and BCC. RESULTS: A 1.5 x 1.5-cm irregular brown lesion on the back was clinically suggestive of MM. Histopathologically, the lesions turned out to be a combined tumor consisting of a superficial BCC and a regressive MM with a tumor thickness of 1.25 mm. The conglomerates of the BCC lay within the MM and were admixed with a high number of Melan-A-positive melanocytic cells. CONCLUSION: By reviewing the low number of published cases, we found that a combined MM-BCC tumor exists in two variants: a collision type in which components of each cell type are clearly demarcated and an intermingled type in which both cell types grow intimately together. Although both types occur as a mere incidence, in particular, the intermingled type may be diagnostically challenging and the evaluation of its dignity may be questionable.
BACKGROUND: The combination of malignant melanoma (MM) and basal cell carcinoma (BCC) within a single tumor is an unusual finding. CASE REPORT: An 84-year-old white man with a pigmented tumor on the back showing a combination of MM and BCC. RESULTS: A 1.5 x 1.5-cm irregular brown lesion on the back was clinically suggestive of MM. Histopathologically, the lesions turned out to be a combined tumor consisting of a superficial BCC and a regressive MM with a tumor thickness of 1.25 mm. The conglomerates of the BCC lay within the MM and were admixed with a high number of Melan-A-positive melanocytic cells. CONCLUSION: By reviewing the low number of published cases, we found that a combined MM-BCC tumor exists in two variants: a collision type in which components of each cell type are clearly demarcated and an intermingled type in which both cell types grow intimately together. Although both types occur as a mere incidence, in particular, the intermingled type may be diagnostically challenging and the evaluation of its dignity may be questionable.
Authors: Silvia E Mancebo; Michael A Marchetti; Travis J Hollmann; Ashfaq A Marghoob; Klaus J Busam; Allan C Halpern Journal: Dermatol Pract Concept Date: 2015-01-30
Authors: Georgi Tchernev; Ilia Lozev; Ivan Pidakev; Irina Yungareva; Tanya Naskova-Popova; Ivanka Temelkova Journal: Open Access Maced J Med Sci Date: 2018-11-21