| Literature DB >> 17696561 |
Janina Kneipp1, Harald Kneipp, Burghardt Wittig, Katrin Kneipp.
Abstract
We demonstrate spatially resolved probing and imaging of pH in live cells by mobile and biocompatible nanosensors using surface-enhanced Raman scattering (SERS) of 4-mercaptobenzoic acid (pMBA) on gold nanoaggregates. Moreover, we also show that this concept of pH nanosensors can be extended to two-photon excitation by using surface-enhanced hyper-Raman scattering (SEHRS). In addition to the advantages of two-photon excitation, the SEHRS sensor enables measurements over a wide pH range without the use of multiple probes.Entities:
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Year: 2007 PMID: 17696561 DOI: 10.1021/nl071418z
Source DB: PubMed Journal: Nano Lett ISSN: 1530-6984 Impact factor: 11.189