BACKGROUND: Angiogenesis is involved in the development of cancer, promoting tumor growth, invasiveness and metastasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. The present case control study was carried out, to determine whether there is an association between the VEGF -2578C > A polymorphism and colon cancer. PATIENTS AND METHODS: DNA samples taken from 246 patients with colon cancer and 203 healthy controls were amplified by polymerase chain reaction for VEGF -2578C > A polymorphism. RESULTS: Genotype frequencies of the VEGF -2578C > A polymorphism were not significantly different between patient and control groups. However, when the data were stratified by gender, the frequency of the -2578CA + AA (A allele-bearing) genotype was marginally significant different with protective effect for colon cancer in women (odds ratio, OR, 0.60; 95% confidence interval, CI, 0.36-0.99; p = 0.056). The -2578CA + AA genotype was also associated with reduced risk in patients with proximal colon cancer (OR, 0.55; 95% CI, 0.31-0.97; p = 0.049). This association also remained in women with proximal colon cancer. CONCLUSION: Although the VEGF -2578C > A polymorphism had no influence on susceptibility to colon cancer, some genotypes showed a significant difference between the case and control groups when the data were stratified by gender and the original location of tumor, suggesting that the VEGF -2578C > A polymorphism, at least in Koreans, is a genetic determinant of colon cancer risk.
BACKGROUND: Angiogenesis is involved in the development of cancer, promoting tumor growth, invasiveness and metastasis. Vascular endothelial growth factor (VEGF) is a potent angiogenic factor. The present case control study was carried out, to determine whether there is an association between the VEGF -2578C > A polymorphism and colon cancer. PATIENTS AND METHODS: DNA samples taken from 246 patients with colon cancer and 203 healthy controls were amplified by polymerase chain reaction for VEGF -2578C > A polymorphism. RESULTS: Genotype frequencies of the VEGF -2578C > A polymorphism were not significantly different between patient and control groups. However, when the data were stratified by gender, the frequency of the -2578CA + AA (A allele-bearing) genotype was marginally significant different with protective effect for colon cancer in women (odds ratio, OR, 0.60; 95% confidence interval, CI, 0.36-0.99; p = 0.056). The -2578CA + AA genotype was also associated with reduced risk in patients with proximal colon cancer (OR, 0.55; 95% CI, 0.31-0.97; p = 0.049). This association also remained in women with proximal colon cancer. CONCLUSION: Although the VEGF -2578C > A polymorphism had no influence on susceptibility to colon cancer, some genotypes showed a significant difference between the case and control groups when the data were stratified by gender and the original location of tumor, suggesting that the VEGF -2578C > A polymorphism, at least in Koreans, is a genetic determinant of colon cancer risk.
Authors: Bryan P Schneider; Molin Wang; Milan Radovich; George W Sledge; Sunil Badve; Ann Thor; David A Flockhart; Bradley Hancock; Nancy Davidson; Julie Gralow; Maura Dickler; Edith A Perez; Melody Cobleigh; Tamara Shenkier; Susan Edgerton; Kathy D Miller Journal: J Clin Oncol Date: 2008-10-01 Impact factor: 44.544
Authors: Asieh Golozar; Terri H Beaty; Patti E Gravitt; Ingo Ruczinski; You-Lin Qiao; Jin-Hu Fan; Ti Ding; Ze-Zhong Tang; Arash Etemadi; Nan Hu; Paula L Hyland; Lemin Wang; Chaoyu Wang; Sanford M Dawsey; Neal D Freedman; Christian C Abnet; Alisa M Goldstein; Philip R Taylor Journal: Eur J Cancer Date: 2014-08-26 Impact factor: 9.162
Authors: Lokesh Jain; Craig A Vargo; Romano Danesi; Tristan M Sissung; Douglas K Price; David Venzon; Jürgen Venitz; William D Figg Journal: Mol Cancer Ther Date: 2009-09-15 Impact factor: 6.261
Authors: Sara Remuzgo-Martínez; Fernanda Genre; Verónica Pulito-Cueto; Belén Atienza-Mateo; Víctor Manuel Mora Cuesta; David Iturbe Fernández; Sonia María Fernández Rozas; Leticia Lera-Gómez; Pilar Alonso Lecue; María Piedad Ussetti; Rosalía Laporta; Cristina Berastegui; Amparo Solé; Virginia Pérez; Alicia De Pablo Gafas; Oreste Gualillo; José Manuel Cifrián; Raquel López-Mejías; Miguel Ángel González-Gay Journal: Biomedicines Date: 2021-04-22