BACKGROUND: The aim of this study was to evaluate immunohistochemical markers in pancreatic cancer and to determine the association of their expression with clinicopathological features and prognosis. PATIENTS AND METHODS: Thirty pancreatic adenocarcinoma patients were followed-up for an average period of 5 years. FAS, bcl-2, p53 and Ki-67 expression were detected immunohistochemically to determine their prognostic value. RESULTS: FAS was statistically associated with p53 (p = 0.002), Ki-67 (p = 0.003), higher histological grade (p = 0.001 and recurrence and overall survival (p = 0.001). CONCLUSION: The newly found overexpression of FAS in highly aggressive pancreatic carcinomas may help us stratify patients into different prognostic groups and indicate new therapeutic strategies.
BACKGROUND: The aim of this study was to evaluate immunohistochemical markers in pancreatic cancer and to determine the association of their expression with clinicopathological features and prognosis. PATIENTS AND METHODS: Thirty pancreatic adenocarcinomapatients were followed-up for an average period of 5 years. FAS, bcl-2, p53 and Ki-67 expression were detected immunohistochemically to determine their prognostic value. RESULTS:FAS was statistically associated with p53 (p = 0.002), Ki-67 (p = 0.003), higher histological grade (p = 0.001 and recurrence and overall survival (p = 0.001). CONCLUSION: The newly found overexpression of FAS in highly aggressive pancreatic carcinomas may help us stratify patients into different prognostic groups and indicate new therapeutic strategies.
Authors: Jian Hua Mao; Rong Ping Zhou; Ai Fen Peng; Zhi Li Liu; Shan Hu Huang; Xin Hua Long; Yong Shu Journal: Oncol Lett Date: 2012-08-16 Impact factor: 2.967
Authors: J Cheng; R P Ondracek; D C Mehedint; K A Kasza; B Xu; S Gill; G Azabdaftari; S Yao; C D Morrison; J L Mohler; J R Marshall Journal: Prostate Cancer Prostatic Dis Date: 2015-04-14 Impact factor: 5.554
Authors: Xuan Yin Chen; Hui Bing Ruan; Xin Hua Long; Ai Fen Peng; Long Dian Zhou; Jia Ming Liu; Yang Zhou; Zhi Li Liu Journal: Exp Ther Med Date: 2017-03-29 Impact factor: 2.447
Authors: Mazhar Al-Zoubi; Galina Chipitsyna; Shivam Saxena; Konrad Sarosiek; Ankit Gandhi; Christopher Y Kang; Daniel Relles; Jocelyn Andrelsendecki; Terry Hyslop; Charles J Yeo; Hwyda A Arafat Journal: J Gastrointest Surg Date: 2013-10-04 Impact factor: 3.452