BACKGROUND: The incidence of brain metastases (BM) is apparently rising in patients with advanced breast cancer (ABC). We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases. PATIENTS AND METHODS: From March 1999 to May 2006, we identified 72 patients with symptomatic BM of breast cancer. A comparison group was randomly selected assigning to each case two patients with primary breast cancer and no BM, matched for year of diagnosis, age and tumour stage (pT status and nodal status). RESULTS: Cases had a significantly higher rate of negative estrogen receptors (ERs) (60% in cases vs. 29% in controls), negative progesterone receptors (PgRs) (79% vs. 43%), HER2/neu over expression (44% vs. 13%) and immunostaining for Ki-67 > or =20% (84% vs. 55%), with p-value <0.001 for all four parameters in univariate analyses. On multivariate analysis, HER2/neu over expression and Ki-67 -20% were independent predictive factors of brain relapse (Odds Ratio (OR) 2.55, 95% confidence intervals (CI) 1.10-5.94 and OR 2.97, 95% CI 1.01-8.73, respectively). Endocrine unresponsive tumours (both ER and PgR <10%) showed an increased risk of relapse with BM of borderline significance (OR 1.91, 95% CI 0.87-4.12). CONCLUSION: Patients with ER and PgR negative tumours either with or without HER-2/neu over expression should be considered at higher risk of BM.
BACKGROUND: The incidence of brain metastases (BM) is apparently rising in patients with advanced breast cancer (ABC). We performed a case control study to define current features of breast cancer related to central nervous system (CNS) metastases. PATIENTS AND METHODS: From March 1999 to May 2006, we identified 72 patients with symptomatic BM of breast cancer. A comparison group was randomly selected assigning to each case two patients with primary breast cancer and no BM, matched for year of diagnosis, age and tumour stage (pT status and nodal status). RESULTS: Cases had a significantly higher rate of negative estrogen receptors (ERs) (60% in cases vs. 29% in controls), negative progesterone receptors (PgRs) (79% vs. 43%), HER2/neu over expression (44% vs. 13%) and immunostaining for Ki-67 > or =20% (84% vs. 55%), with p-value <0.001 for all four parameters in univariate analyses. On multivariate analysis, HER2/neu over expression and Ki-67 -20% were independent predictive factors of brain relapse (Odds Ratio (OR) 2.55, 95% confidence intervals (CI) 1.10-5.94 and OR 2.97, 95% CI 1.01-8.73, respectively). Endocrine unresponsive tumours (both ER and PgR <10%) showed an increased risk of relapse with BM of borderline significance (OR 1.91, 95% CI 0.87-4.12). CONCLUSION:Patients with ER and PgR negative tumours either with or without HER-2/neu over expression should be considered at higher risk of BM.
Authors: Elisabeth Bergen; Anna S Berghoff; Margaretha Rudas; Peter Dubsky; Catharina De Vries; Claudia Sattlberger; Robert M Mader; Flora Zagouri; Cornelia Sparber; Florian Fitzal; Michael Gnant; Andrea Rottenfusser; Christoph C Zielinski; Matthias Preusser; Guenther G Steger; Rupert Bartsch Journal: Breast Care (Basel) Date: 2014-10 Impact factor: 2.860
Authors: Amélie Darlix; Gaia Griguolo; Simon Thezenas; Eva Kantelhardt; Christoph Thomssen; Maria Vittoria Dieci; Federica Miglietta; PierFranco Conte; Antoine Laurent Braccini; Jean Marc Ferrero; Caroline Bailleux; William Jacot; Valentina Guarneri Journal: J Neurooncol Date: 2018-02-27 Impact factor: 4.130
Authors: P Pittoni; S Di Lascio; M Conti-Beltraminelli; M C Valli; V Espeli; M Bongiovanni; A Richetti; O Pagani Journal: BMJ Case Rep Date: 2014-06-27
Authors: Markus Kuksis; Yizhuo Gao; William Tran; Christianne Hoey; Alex Kiss; Adam S Komorowski; Aman J Dhaliwal; Arjun Sahgal; Sunit Das; Kelvin K Chan; Katarzyna J Jerzak Journal: Neuro Oncol Date: 2021-06-01 Impact factor: 12.300
Authors: Hee Kyung Ahn; Yeon Hee Park; Su Jin Lee; Silvia Park; Chi Hoon Maeng; Won Park; Doo Ho Choi; Seung Jae Hur; Jin Seok Ahn; Young-Hyuck Im Journal: Springerplus Date: 2013-03-28