UNLABELLED: The objective of this study was to define the prognostic factors for survival of patients with soft tissue sarcomas (STS) of the extremities located below the muscular fascia. PATIENTS AND METHODS: One hundred and twenty-seven consecutive patients, resected in our Institution between March 1988 and December 2002, were reviewed. RESULTS: On univariate analysis, the prognostic factors for survival were tumor size, nodal status, adequate surgery, tumor malignancy grade and administered chemotherapy. Additionally, local failure, metastasis after resection and residual tumor after incomplete resection followed by complete resection were adverse prognostic factors for survival. The tumor size, nodal status and metastasis after resection were factors indicating worse survival on multivariate analysis. CONCLUSION: Our results indicate that most factors influencing the course of the disease cannot be controlled by the surgeon. Complete resection is imperative for local control and allows the patient the chance of a cure. New treatment procedures should be evaluated in prospective trials to optimize therapy. Surgery without sufficient information on the malignancy or expansion of the tumor might be detrimental for the patient.
UNLABELLED: The objective of this study was to define the prognostic factors for survival of patients with soft tissue sarcomas (STS) of the extremities located below the muscular fascia. PATIENTS AND METHODS: One hundred and twenty-seven consecutive patients, resected in our Institution between March 1988 and December 2002, were reviewed. RESULTS: On univariate analysis, the prognostic factors for survival were tumor size, nodal status, adequate surgery, tumor malignancy grade and administered chemotherapy. Additionally, local failure, metastasis after resection and residual tumor after incomplete resection followed by complete resection were adverse prognostic factors for survival. The tumor size, nodal status and metastasis after resection were factors indicating worse survival on multivariate analysis. CONCLUSION: Our results indicate that most factors influencing the course of the disease cannot be controlled by the surgeon. Complete resection is imperative for local control and allows the patient the chance of a cure. New treatment procedures should be evaluated in prospective trials to optimize therapy. Surgery without sufficient information on the malignancy or expansion of the tumor might be detrimental for the patient.
Authors: Peter A Pellionisz; Nikan K Namiri; Gregory Suematsu; Yong Hu; Ameet Braganza; Khuzaima Rangwalla; Daniel J Denson; Karam Badran; Nathan C Francis; Ashkan Maccabi; George Saddik; Zachary Taylor; Maie A St John; Warren S Grundfest Journal: Yale J Biol Med Date: 2018-09-21