H Ueno1, K Yoshioka, T Matsumoto. 1. Department of Child Development, Graduate School of Medical Sciences, School of Medicine, Kumamoto University, Kumamoto, Japan.
Abstract
BACKGROUND: The diagnostic accuracy of the skin prick test (SPT) for food allergies remains to be fully accepted and substantial individual differences in the prevalence of skin test reactivity have been reported. OBJECTIVE: The aim of this study was to assess the diagnostic value of absolute wheal size and skin index (SI; ratio of food allergen-induced wheal to histamine-induced wheal) according to the outcome of controlled oral food challenges. METHODS: Eighty-seven controlled oral challenges were performed with cow's milk, hen eggs, wheat, buckwheat, peanuts, seafood, and/or fruit in 51 children (median age, 35 months). The wheal diameters in SPT, the SI, and the serum specific immunoglobulin (Ig) E concentrations were determined. RESULTS: Thirty-three oral challenges were assessed as being positive. SI and wheal diameter in SPT were both significantly different according to the outcome of food challenge (P < .001 and P = .03, respectively); the greatest difference was found in the case of SI. Serum specific IgE concentration did not differ significantly according to the outcome of food challenge. CONCLUSION: SI may be helpful for predicting a positive outcome of food challenge.
BACKGROUND: The diagnostic accuracy of the skin prick test (SPT) for food allergies remains to be fully accepted and substantial individual differences in the prevalence of skin test reactivity have been reported. OBJECTIVE: The aim of this study was to assess the diagnostic value of absolute wheal size and skin index (SI; ratio of food allergen-induced wheal to histamine-induced wheal) according to the outcome of controlled oral food challenges. METHODS: Eighty-seven controlled oral challenges were performed with cow's milk, hen eggs, wheat, buckwheat, peanuts, seafood, and/or fruit in 51 children (median age, 35 months). The wheal diameters in SPT, the SI, and the serum specific immunoglobulin (Ig) E concentrations were determined. RESULTS: Thirty-three oral challenges were assessed as being positive. SI and wheal diameter in SPT were both significantly different according to the outcome of food challenge (P < .001 and P = .03, respectively); the greatest difference was found in the case of SI. Serum specific IgE concentration did not differ significantly according to the outcome of food challenge. CONCLUSION: SI may be helpful for predicting a positive outcome of food challenge.
Authors: S Geiselhart; C Nagl; P Dubiela; A C Pedersen; M Bublin; C Radauer; C Bindslev-Jensen; K Hoffmann-Sommergruber; C G Mortz Journal: Clin Exp Allergy Date: 2017-12-22 Impact factor: 5.018
Authors: Zeinab A El-Sayed; Dalia H El-Ghoneimy; Dina El-Shennawy; Manar W Nasser Journal: Allergy Asthma Immunol Res Date: 2013-02-04 Impact factor: 5.764