Literature DB >> 17694066

Clearance of amyloid-beta by circulating lipoprotein receptors.

Abhay Sagare1, Rashid Deane, Robert D Bell, Bradley Johnson, Katie Hamm, Ronan Pendu, Andrew Marky, Peter J Lenting, Zhenhua Wu, Troy Zarcone, Alison Goate, Kevin Mayo, David Perlmutter, Mireia Coma, Zhihui Zhong, Berislav V Zlokovic.   

Abstract

Low-density lipoprotein receptor-related protein-1 (LRP) on brain capillaries clears amyloid beta-peptide (Abeta) from brain. Here, we show that soluble circulating LRP (sLRP) provides key endogenous peripheral 'sink' activity for Abeta in humans. Recombinant LRP cluster IV (LRP-IV) bound Abeta in plasma in mice and Alzheimer's disease-affected humans with compromised sLRP-mediated Abeta binding, and reduced Abeta-related pathology and dysfunction in a mouse model of Alzheimer disease, suggesting that LRP-IV can effectively replace native sLRP and clear Abeta.

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Year:  2007        PMID： 17694066      PMCID： PMC2936449          DOI： 10.1038/nm1635

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   53.440


  15 in total

1.  Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.

Authors:  Yasuji Matsuoka; Mitsuo Saito; John LaFrancois; Mariko Saito; Kate Gaynor; Vicki Olm; Lili Wang; Evelyn Casey; Yifan Lu; Chiharu Shiratori; Cynthia Lemere; Karen Duff
Journal:  J Neurosci       Date:  2003-01-01       Impact factor: 6.167

2.  Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls.

Authors:  Samir Kumar-Singh; Daniel Pirici; Eileen McGowan; Sally Serneels; Chantal Ceuterick; John Hardy; Karen Duff; Dennis Dickson; Christine Van Broeckhoven
Journal:  Am J Pathol       Date:  2005-08       Impact factor: 4.307

3.  Soluble low density lipoprotein receptor-related protein (LRP) circulates in human plasma.

Authors:  K A Quinn; P G Grimsley; Y P Dai; M Tapner; C N Chesterman; D A Owensby
Journal:  J Biol Chem       Date:  1997-09-19       Impact factor: 5.157

4.  Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.

Authors:  John D Fryer; Kelly Simmons; Maia Parsadanian; Kelly R Bales; Steven M Paul; Patrick M Sullivan; David M Holtzman
Journal:  J Neurosci       Date:  2005-03-16       Impact factor: 6.167

Review 5.  LRP and Alzheimer's disease.

Authors:  Celina V Zerbinatti; Guojun Bu
Journal:  Rev Neurosci       Date:  2005       Impact factor: 4.353

6.  The alpha -chains of C4b-binding protein mediate complex formation with low density lipoprotein receptor-related protein.

Authors:  Erik Westein; Cecile V Denis; Bonno N Bouma; Peter J Lenting
Journal:  J Biol Chem       Date:  2001-11-08       Impact factor: 5.157

7.  The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate.

Authors:  Christine A F von Arnim; Ayae Kinoshita; Ithan D Peltan; Michelle M Tangredi; Lauren Herl; Bonny M Lee; Robert Spoelgen; Tammy T Hshieh; Sripriya Ranganathan; Frances D Battey; Chun-Xiang Liu; Brian J Bacskai; Sanja Sever; Michael C Irizarry; Dudley K Strickland; Bradley T Hyman
Journal:  J Biol Chem       Date:  2005-03-04       Impact factor: 5.157

Review 8.  Clearance of Alzheimer's Abeta peptide: the many roads to perdition.

Authors:  R E Tanzi; R D Moir; S L Wagner
Journal:  Neuron       Date:  2004-09-02       Impact factor: 17.173

9.  Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice.

Authors:  K Hsiao; P Chapman; S Nilsen; C Eckman; Y Harigaya; S Younkin; F Yang; G Cole
Journal:  Science       Date:  1996-10-04       Impact factor: 47.728

10.  LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms.

Authors:  Rashid Deane; Zhenhua Wu; Abhay Sagare; Judianne Davis; Shi Du Yan; Katie Hamm; Feng Xu; Margaret Parisi; Barbra LaRue; Hong Wei Hu; Patricia Spijkers; Huang Guo; Xiaomei Song; Peter J Lenting; William E Van Nostrand; Berislav V Zlokovic
Journal:  Neuron       Date:  2004-08-05       Impact factor: 17.173
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  174 in total

1.  The expression of LDL receptor in vessels with blood-brain barrier impairment in a stroke-prone hypertensive model.

Authors:  Masaki Ueno; Bin Wu; Toshitaka Nakagawa; Yukiko Nagai; Masayuki Onodera; Cheng-Long Huang; Takashi Kusaka; Kenji Kanenishi; Haruhiko Sakamoto
Journal:  Histochem Cell Biol       Date:  2010-05-11       Impact factor: 4.304

2.  miR-285-Yki/Mask double-negative feedback loop mediates blood-brain barrier integrity in Drosophila.

Authors:  Dong Li; Yanling Liu; Chunli Pei; Peng Zhang; Linqing Pan; Jing Xiao; Songshu Meng; Zengqiang Yuan; Xiaolin Bi
Journal:  Proc Natl Acad Sci U S A       Date:  2017-03-06       Impact factor: 11.205

3.  A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease.

Authors:  Rashid Deane; Itender Singh; Abhay P Sagare; Robert D Bell; Nathan T Ross; Barbra LaRue; Rachal Love; Sheldon Perry; Nicole Paquette; Richard J Deane; Meenakshisundaram Thiyagarajan; Troy Zarcone; Gunter Fritz; Alan E Friedman; Benjamin L Miller; Berislav V Zlokovic
Journal:  J Clin Invest       Date:  2012-03-12       Impact factor: 14.808

4.  Amyloid-β contributes to blood-brain barrier leakage in transgenic human amyloid precursor protein mice and in humans with cerebral amyloid angiopathy.

Authors:  Anika M S Hartz; Björn Bauer; Emma L B Soldner; Andrea Wolf; Sandra Boy; Roland Backhaus; Ivan Mihaljevic; Ulrich Bogdahn; Hans H Klünemann; Gerhard Schuierer; Felix Schlachetzki
Journal:  Stroke       Date:  2011-11-23       Impact factor: 7.914

5.  Preferential interactions between ApoE-containing lipoproteins and Aβ revealed by a detection method that combines size exclusion chromatography with non-reducing gel-shift.

Authors:  Mary Jo LaDu; Gregory W Munson; Lisa Jungbauer; Godfrey S Getz; Catherine A Reardon; Leon M Tai; Chunjiang Yu
Journal:  Biochim Biophys Acta       Date:  2011-11-23

Review 6.  Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders.

Authors:  Berislav V Zlokovic
Journal:  Nat Rev Neurosci       Date:  2011-11-03       Impact factor: 34.870

7.  Extracting β-amyloid from Alzheimer's disease.

Authors:  Daniel R Dries; Gang Yu; Joachim Herz
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-10       Impact factor: 11.205

Review 8.  Dyslipidemia and dementia: current epidemiology, genetic evidence, and mechanisms behind the associations.

Authors:  Christiane Reitz
Journal:  J Alzheimers Dis       Date:  2012       Impact factor: 4.472

Review 9.  Current therapeutic targets for the treatment of Alzheimer's disease.

Authors:  Joshua D Grill; Jeffrey L Cummings
Journal:  Expert Rev Neurother       Date:  2010-05       Impact factor: 4.618

Review 10.  Lipoprotein receptors--an evolutionarily ancient multifunctional receptor family.

Authors:  Marco Dieckmann; Martin Frederik Dietrich; Joachim Herz
Journal:  Biol Chem       Date:  2010-11       Impact factor: 3.915
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