| Literature DB >> 17692848 |
Yan Yu1, Zhi-biao Yi, Yi-Zeng Liang.
Abstract
In this investigation, the antibacterial modes of action of Radix Tinosporae, its major single components, and nine antibiotics with different targets or modes-of-action on Staphylococcus aureus were studied. Metabolic profiles of cultures treated with different medicines were acquired by HPLC/ESI-MS. After HPLC-MS data pretreatment, those profiles acquired were reduced into several MS vectors. Then statistical processing by principal components analysis was carried out upon those vectors, two conclusions could be drawn: (1) the antibacterial mode of action of Radix Tinosporae is similar to that of rifampicin and norfloxacin, which act on nucleic acid; (2) its active components playing main antimicrobial roles on Staphylococcus aureus might be alkaloids, such as palmatine and jatrorrhizine.Entities:
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Year: 2007 PMID： 17692848 DOI： 10.1016/j.febslet.2007.07.056
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124