| Literature DB >> 17692518 |
Subharekha Raghavan1, Zhijian Lu, Teresa Beeson, Kevin T Chapman, William A Schleif, David B Olsen, Mark Stahlhut, Carrie A Rutkowski, Lori Gabryelski, Emilio Emini, James R Tata.
Abstract
A series of HIV protease inhibitors with modifications on the P3 position have been designed and synthesized. These compounds exhibit excellent antiviral activity against both the wild type enzyme and PI-resistant clinical viral isolates. The synthesis and biological activity of the compounds are described.Mesh：
Substances：
Year: 2007 PMID： 17692518 DOI： 10.1016/j.bmcl.2007.07.040
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823