| Literature DB >> 17692350 |
Miriam Rega1, Carlos Jiménez, Jaime Rodríguez.
Abstract
A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), colon adenocarcinoma HCT-116 (ATCC CCL-247), human caucasian glioblastoma multiforme T98G (ECACC 92090213) and human pancreatic adenocarcinoma PSN1 (ECACC 94060601) tumour cells. Homodimer 10b presented selective activity against HCT-116, although they are not highly toxic when compared with the monomer counterparts.Entities:
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Year: 2007 PMID： 17692350 DOI： 10.1016/j.steroids.2007.03.014
Source DB: PubMed Journal: Steroids ISSN： 0039-128X Impact factor: 2.668