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Literature DB >> 17691795

Trivalent antigens for degranulation of mast cells.

Richard G Posner¹, Dianliang Geng, Seth Haymore, James Bogert, Israel Pecht, Arieh Licht, Paul B Savage.

Abstract

Degranulation of basophils and mast cells plays a central role in allergic reactions. Degranulation is a response to cell surface receptor aggregation caused by association of receptors with antibodies bound to multivalent antigens. Tools used in studying this process have included small-molecule divalent antigens, but they suffer from weak signaling apparently due to small aggregate size. We have prepared trivalent antigens that allow formation of larger aggregates and potent responses from mast cells.

Entities: Disease

Mesh：

Substances：
Antigens
Hexosaminidases

Year: 2007 PMID： 17691795 PMCID： PMC3305801 DOI： 10.1021/ol071175h

Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005

18 in total

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Journal: J Immunol Date: 1992-09-01 Impact factor: 5.422

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Journal: Mol Immunol Date: 2002-09 Impact factor: 4.407

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Journal: Immunol Today Date: 1992-02

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Journal: J Cell Physiol Date: 1990-07 Impact factor: 6.384

5. Larger oligomers of IgE are more effective than dimers in stimulating rat basophilic leukemia cells.

Authors: C Fewtrell; H Metzger
Journal: J Immunol Date: 1980-08 Impact factor: 5.422

6. Design and synthesis of novel N-acetylgalactosamine-terminated glycolipids for targeting of lipoproteins to the hepatic asialoglycoprotein receptor.

Authors: Patrick C N Rensen; Steven H van Leeuwen; Leo A J M Sliedregt; Theo J C van Berkel; Erik A L Biessen
Journal: J Med Chem Date: 2004-11-04 Impact factor: 7.446

7. A synthetic trivalent hapten that aggregates anti-2,4-DNP IgG into bicyclic trimers.

Authors: Basar Bilgiçer; Demetri T Moustakas; George M Whitesides
Journal: J Am Chem Soc Date: 2007-02-28 Impact factor: 15.419

8. Highly effective poly(ethylene glycol) architectures for specific inhibition of immune receptor activation.

Authors: Emily J Baird; David Holowka; Geoffrey W Coates; Barbara Baird
Journal: Biochemistry Date: 2003-11-11 Impact factor: 3.162

9. Dimerization kinetics of the IgE-class antibodies by divalent haptens. II. The interactions between intact IgE and haptens.

Authors: R Schweitzer-Stenner; A Licht; I Pecht
Journal: Biophys J Date: 1992-08 Impact factor: 4.033

10. Cross-linking of IgE-receptor complexes at the cell surface: synthesis and characterization of a long bivalent hapten that is capable of triggering mast cells and rat basophilic leukemia cells.

Authors: P Kane; J Erickson; C Fewtrell; B Baird; D Holowka
Journal: Mol Immunol Date: 1986-07 Impact factor: 4.407

16 in total

1. Simulation of large-scale rule-based models.

Authors: Joshua Colvin; Michael I Monine; James R Faeder; William S Hlavacek; Daniel D Von Hoff; Richard G Posner
Journal: Bioinformatics Date: 2009-02-11 Impact factor: 6.937

2. Modeling multivalent ligand-receptor interactions with steric constraints on configurations of cell-surface receptor aggregates.

Authors: Michael I Monine; Richard G Posner; Paul B Savage; James R Faeder; William S Hlavacek
Journal: Biophys J Date: 2010-01-06 Impact factor: 4.033

3. The efficiency of reactant site sampling in network-free simulation of rule-based models for biochemical systems.

Authors: Jin Yang; William S Hlavacek
Journal: Phys Biol Date: 2011-08-10 Impact factor: 2.583

4. Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation.

Authors: Michael W Handlogten; Tanyel Kiziltepe; Basar Bilgicer
Journal: Biochem J Date: 2013-01-01 Impact factor: 3.857

Review 5. Spatio-temporal signaling in mast cells.

Authors: Bridget S Wilson; Janet M Oliver; Diane S Lidke
Journal: Adv Exp Med Biol Date: 2011 Impact factor: 2.622

6. Synthetic allergen design reveals the significance of moderate affinity epitopes in mast cell degranulation.

Authors: Michael W Handlogten; Tanyel Kiziltepe; Nathan J Alves; Basar Bilgicer
Journal: ACS Chem Biol Date: 2012-08-21 Impact factor: 5.100

7. Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation.

Authors: Michael W Handlogten; Tanyel Kiziltepe; Ana P Serezani; Mark H Kaplan; Basar Bilgicer
Journal: Nat Chem Biol Date: 2013-10-06 Impact factor: 15.040

8. Kinetic Monte Carlo method for rule-based modeling of biochemical networks.

Authors: Jin Yang; Michael I Monine; James R Faeder; William S Hlavacek
Journal: Phys Rev E Stat Nonlin Soft Matter Phys Date: 2008-09-10

9. Nanoparticle-mediated IgE-receptor aggregation and signaling in RBL mast cells.

Authors: Yu-Fen Huang; Haipeng Liu; Xiangling Xiong; Yan Chen; Weihong Tan
Journal: J Am Chem Soc Date: 2009-12-02 Impact factor: 15.419

10. Formation of a mast cell synapse: Fc epsilon RI membrane dynamics upon binding mobile or immobilized ligands on surfaces.

Authors: Amanda Carroll-Portillo; Kathrin Spendier; Janet Pfeiffer; Gary Griffiths; Haitao Li; Keith A Lidke; Janet M Oliver; Diane S Lidke; James L Thomas; Bridget S Wilson; Jerilyn A Timlin
Journal: J Immunol Date: 2009-12-30 Impact factor: 5.422