Literature DB >> 17691032

Executive function is associated with brain proton magnetic resonance spectroscopy in amnestic mild cognitive impairment.

H Randall Griffith1, Jan A den Hollander, Ozioma Okonkwo, William T Evanochko, Lindy E Harrell, Edward Y Zamrini, John C Brockington, Daniel C Marson.   

Abstract

Persons with amnestic mild cognitive impairment (MCI) show deficits on executive function measures, although the neuroanatomic basis of executive function in MCI is unknown. We investigated cognitive correlates of 3-tesla proton magnetic resonance spectroscopy (MRS) of the posterior cingulate gyrus in 26 MCI patients. Posterior cingulate ratio of myo-inositol to creatine (mI/Cr) was negatively correlated (-.51) with spontaneous clock drawing. This relationship was not attenuated after accounting for age, overall cognitive function, or memory performance. This finding suggests a role for the posterior cingulate in executive function in MCI. Proton MRS may offer a means to track neurometabolic changes associated with cognitive impairment in MCI.

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Year:  2007        PMID： 17691032     DOI： 10.1080/13803390600826595

Source DB:  PubMed          Journal:  J Clin Exp Neuropsychol        ISSN： 1380-3395            Impact factor:   2.475


  7 in total

1.  Brain metabolic correlates of decision making in amnestic mild cognitive impairment.

Authors:  H Randall Griffith; Ozioma C Okonkwo; Jan A den Hollander; Katherine Belue; Jacqueline Copeland; Lindy E Harrell; John C Brockington; David G Clark; Daniel C Marson
Journal:  Neuropsychol Dev Cogn B Aging Neuropsychol Cogn       Date:  2010-04-06

2.  Indirect effects of elevated body mass index on memory performance through altered cerebral metabolite concentrations.

Authors:  Mitzi M Gonzales; Takashi Tarumi; Danielle E Eagan; Hirofumi Tanaka; Miral Vaghasia; Andreana P Haley
Journal:  Psychosom Med       Date:  2012-07-20       Impact factor: 4.312

3.  Semantic clustering as a neuropsychological predictor for amnestic-MCI.

Authors:  Michael Malek-Ahmadi; Ashok Raj; Brent J Small
Journal:  Neuropsychol Dev Cogn B Aging Neuropsychol Cogn       Date:  2011-02-22

4.  Aerobic fitness and the brain: increased N-acetyl-aspartate and choline concentrations in endurance-trained middle-aged adults.

Authors:  Mitzi M Gonzales; Takashi Tarumi; Sonya Kaur; Nantinee Nualnim; Bennett A Fallow; Martha Pyron; Hirofumi Tanaka; Andreana P Haley
Journal:  Brain Topogr       Date:  2012-08-28       Impact factor: 3.020

5.  Patterns of cerebral hypoperfusion in amnestic and dysexecutive MCI.

Authors:  Linda L Chao; Judy Pa; Audrey Duarte; Norbert Schuff; Michael W Weiner; Joel H Kramer; Bruce L Miller; Katie M Freeman; Julene K Johnson
Journal:  Alzheimer Dis Assoc Disord       Date:  2009 Jul-Sep       Impact factor: 2.703

6.  Mild cognitive impairment: The dilemma.

Authors:  Charles Pinto; Alka A Subramanyam
Journal:  Indian J Psychiatry       Date:  2009-01       Impact factor: 1.759

Review 7.  Advances in high-field magnetic resonance spectroscopy in Alzheimer's disease.

Authors:  Ningnannan Zhang; Xiaowei Song; Robert Bartha; Steven Beyea; Ryan D'Arcy; Yunting Zhang; Kenneth Rockwood
Journal:  Curr Alzheimer Res       Date:  2014-05       Impact factor: 3.498
  7 in total

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