| Literature DB >> 17690709 |
Caryn Lerman1, Mark G LeSage, Kenneth A Perkins, Stephanie S O'Malley, Steven J Siegel, Neal L Benowitz, William A Corrigall.
Abstract
A major obstacle to the development of medications for nicotine dependence is the lack of animal and human laboratory models with sufficient predictive clinical validity to support the translation of knowledge from laboratory studies to clinical research. This Review describes the animal and human laboratory paradigms commonly used to investigate the pathophysiology of nicotine dependence, and proposes how their predictive validity might be determined and improved, thereby enhancing the development of new medications.Entities:
Mesh：
Year: 2007 PMID： 17690709 DOI： 10.1038/nrd2361
Source DB: PubMed Journal: Nat Rev Drug Discov ISSN： 1474-1776 Impact factor: 84.694