Literature DB >> 17689917

Aeromonas hydrophila AH-3 AexT is an ADP-ribosylating toxin secreted through the type III secretion system.

Silvia Vilches1, Markus Wilhelms, Hong Bing Yu, Ka Yin Leung, Juan M Tomás, Susana Merino.   

Abstract

We cloned and sequenced an ADP-ribosylating toxin (AexT) from a mesophilic Aeromonas hydrophila strain AH-3 with a type III secretion system (T3SS). This toxin only showed homology, in genes and proteins, with the first half of A. salmonicida AexT. The A. hydrophila AexT showed ADP-ribosyltransferase activity, translocation through the T3SS system, and this A. hydrophila T3SS system is inducible under calcium-depleted conditions. The A. hydrophila aexT mutant showed a slight reduction in their virulence assayed by several methods when compared to the wild-type strain, while an A. hydrophila T3SS mutant is highly reduced in virulence on the same assays. The A. hydrophila AexT is the first described and the smallest T3SS effector toxin found in mesophilic Aeromonas with a functional T3SS.

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Year:  2007        PMID： 17689917     DOI： 10.1016/j.micpath.2007.06.004

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  18 in total

1.  Mapping of the chaperone AcrH binding regions of translocators AopB and AopD and characterization of oligomeric and metastable AcrH-AopB-AopD complexes in the type III secretion system of Aeromonas hydrophila.

Authors:  Yih Wan Tan; Hong Bing Yu; J Sivaraman; Ka Yin Leung; Yu-Keung Mok
Journal:  Protein Sci       Date:  2009-08       Impact factor: 6.725

Review 2.  Novel bacterial ADP-ribosylating toxins: structure and function.

Authors:  Nathan C Simon; Klaus Aktories; Joseph T Barbieri
Journal:  Nat Rev Microbiol       Date:  2014-07-14       Impact factor: 60.633

3.  Aeromonas hydrophila virulence.

Authors:  Barbara Citterio; Biavasco Francesca
Journal:  Virulence       Date:  2015       Impact factor: 5.882

4.  Photox, a novel actin-targeting mono-ADP-ribosyltransferase from Photorhabdus luminescens.

Authors:  Danielle D Visschedyk; Alexandru A Perieteanu; Zachari J Turgeon; Robert J Fieldhouse; John F Dawson; A Rod Merrill
Journal:  J Biol Chem       Date:  2010-02-24       Impact factor: 5.157

5.  Structure of AscE and induced burial regions in AscE and AscG upon formation of the chaperone needle-subunit complex of type III secretion system in Aeromonas hydrophila.

Authors:  Yih Wan Tan; Hong Bing Yu; Ka Yin Leung; J Sivaraman; Yu-Keung Mok
Journal:  Protein Sci       Date:  2008-07-28       Impact factor: 6.725

6.  Aeromonas hydrophila AH-3 type III secretion system expression and regulatory network.

Authors:  Silvia Vilches; Natalia Jimenez; Juan M Tomás; Susana Merino
Journal:  Appl Environ Microbiol       Date:  2009-08-14       Impact factor: 4.792

7.  Clinical relevance of the recently described species Aeromonas aquariorum.

Authors:  M José Figueras; Anabel Alperi; M José Saavedra; Wen-Chien Ko; Nieves Gonzalo; Maria Navarro; Antonio J Martínez-Murcia
Journal:  J Clin Microbiol       Date:  2009-09-09       Impact factor: 5.948

8.  Crystal structure of the heteromolecular chaperone, AscE-AscG, from the type III secretion system in Aeromonas hydrophila.

Authors:  Chiradip Chatterjee; Sundramurthy Kumar; Smarajit Chakraborty; Yih Wan Tan; Ka Yin Leung; J Sivaraman; Yu-Keung Mok
Journal:  PLoS One       Date:  2011-04-29       Impact factor: 3.240

9.  Molecular characterization of clinical isolates of Aeromonas species from Malaysia.

Authors:  S D Puthucheary; Suat Moi Puah; Kek Heng Chua
Journal:  PLoS One       Date:  2012-02-27       Impact factor: 3.240

10.  The main Aeromonas pathogenic factors.

Authors:  J M Tomás
Journal:  ISRN Microbiol       Date:  2012-09-04
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